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Fig. 1. Loss of circadian rhythms in iKO mice.

Published byΒαυκις Καψής Modified over 5 years ago

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Presentation on theme: "Fig. 1. Loss of circadian rhythms in iKO mice."— Presentation transcript:

1 Fig. 1. Loss of circadian rhythms in iKO mice.
Loss of circadian rhythms in iKO mice. (A) Representative double-plotted actograms of wheel-running activity of 3-month-old Bmal1f/f and Bmal1f/f-EsrCre mice (red dots, tamoxifen treatment). Similar results were obtained in n = 8 to 9 mice per group. (B) Counts of wheel revolutions per hour from control mice (Ctrls) and iKO mice under conditions of DD (n = 8 to 9, Student’s t test; ns, no significant difference). (C) Representative double-plotted actograms of wheel-running activity from 18-month-old Ctrl and iKO mice under DD. Similar results were obtained in n = 6 to 7 mice per group. (D) Counts of wheel revolutions from 18-month-old Ctrls and iKOs under DD (n = 6 to 7; Student’s t test). (E) Representative radiotelemetry results of locomotor activity, systolic BP (SBP), and HR in Bmal1f/f and Bmal1f/f-EsrCre mice (red inverted triangles, tamoxifen treatment). Similar results were obtained in n = 3 mice per group. (F) Hepatic mRNA levels of canonical clock genes and clock-controlled gene Dbp were determined by qRT-PCR [n = 4 per genotype per time point; x axis, circadian time (CT); y axis, relative mRNA levels; *P < 0.05; **P < 0.01; ***P < 0.001, two-way analysis of variance (ANOVA)]. Guangrui Yang et al., Sci Transl Med 2016;8:324ra16 Published by AAAS

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