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Volume 132, Issue 4, Pages (April 2007)

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1 Volume 132, Issue 4, Pages 1254-1260 (April 2007)
Rare CpG Island Methylator Phenotype in Ulcerative Colitis–Associated Neoplasias  Kazuo Konishi, Lanlan Shen, Suna Wang, Stephen J. Meltzer, Noam Harpaz, Jean–Pierre J. Issa  Gastroenterology  Volume 132, Issue 4, Pages (April 2007) DOI: /j.gastro Copyright © 2007 AGA Institute Terms and Conditions

2 Figure 1 Z-score of promoter methylation in UC-associated neoplasias and S-CRCs. Type C genes: MINT1, MINT2, MINT31, hMLH1, p16, and p14; type A genes: HPP1, SFRP1, and ERα. *Significantly different from S-CRCs (P = .009 for type C genes and P < .001 for type A genes). #Significantly different from UC-Cs (P < .001). Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2007 AGA Institute Terms and Conditions

3 Figure 2 Distribution of LINE-1 methylation levels in UC-Ds, UC-Cs, S-CRCs, and colonic mucosa adjacent to S-CRCs. Each dot represents the methylation level of individual samples of UC-Ds (left), UC-Cs (left-middle), S-CRCs (right-middle), and colonic mucosa adjacent to S-CRCs (right). Horizontal lines represent the mean methylation levels for each group. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2007 AGA Institute Terms and Conditions


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