1. SWAG SSG Skin Cancer Meeting
Clinical Research Network
West of England
SWAG SSG Skin Cancer Meeting
Wednesday 13th September 2017
Research Report

2. Clinical Research Network & Cancer Services
West ofEngland
SWAG - Somerset Wiltshire Avon & Gloucestershire
South West Children’s Cancer & Leukaemia
Research Network

3. NIHR CRN High Level Objectives 2017-18
Increase number of participants into NIHR CRN portfolio studies
650,000 in England
21,905 in West of England
Increase the number of studies that deliver to time and target
Target 80%
Increase number of commercial studies delivered through network
Reduce NHS study set up times
Reduce time taken to recruit first participant

4. CRN Cancer Objectives 2017/18
Number of LCRNs achieving on-target recruitment into at least 8 of the 13 Cancer subspecialties, where "on-target" means either improving recruitment by 10% from 2016/17 or meeting the following recruitment targets per 100,000 population served: 
a) Brain & CNS: 0.2; b) Breast: 8; c) Colorectal: 3; d) Paediatrics: 3; e) Gynae: 3; f) Head & Neck: 1; g) Haematology: 7; h) Lung: 4; i) Sarcoma: 0.1; j) Skin: 0.2; k) Supportive & Palliative Care and Psychosocial Oncology & Survivorship: 3; l) Upper GI: 3; m) Urology: 8.

10. Open studies – Skin CPMS ID Study Title Site PI Trial Team Contact
19639
The PERM Study - Randomised Phase II Trial of Pembrolizumab and Radiotherapy in Melanoma
University Hospitals Bristol NHS Foundation Trust
Herbert, Dr Chris
Matt Baxter
20444
Rational MCC - Rational treatment selection for Merkel Cell Carcinoma (MCC): A randomised phase III multi-centre trial comparing radical surgery and radical radiotherapy as first definitive treatment for primary MCC with an observational study for patients ineligible for the randomised trial.
North Bristol NHS Trust
Challapalli, Dr Amarnath
32773
TRILOGY – A Phase III Study of Atezolizumab plus Cobimetinib and Vemurafenib versus Placebo plus Cobimetinib and Vemurafenib in Previously Untreated BRAFV600 Mutation-Positive Patients with Unresectable Locally Advanced or Metastatic Melanoma.
Matt Baxter

11. Studies in set up CPMS ID Study Title Site PI 20657
Minitub - Prospective registry of Sentinel Node (SN) positive melanoma patients with minimal SN tumor burden who undergo Completion Lymph Node Dissection (CLND) or Nodal Observation.
North Bristol NHS Trust
Wilson , Dr Ewan
20841
EAGLE-FM - Evaluation of Groin Lymphadenectomy Extent For Metastatic Melanoma

12. Useful links https://www.crn.nihr.ac.uk/ https://odp.nihr.ac.uk
National and local network information including training programmes templates, tools, contacts, videos etc
Open data platform. Look at performance across whole CRN including all specialty areas
View current national portfolio of open, closed and ‘in set up’ cancer studies
See where a study is open across the country
Search for a study to fit criteria. Good for horizon scanning, eligibility criteria

13. Contacts Research Delivery Manager – david.rea@nihr.ac.uk
Cancer portfolio facilitator –
Skin research lead –