1. SWAG SSG Urology Meeting
Clinical Research Network
West of England
SWAG SSG Urology Meeting
Thursday 13th October 2016
Maxine Taylor
Senior Research Delivery Manager – Cancer, Surgery, Genetics, Haematology.
Workforce Development Lead

2. Clinical Research Network & Cancer Services
West ofEngland
SWAG - Somerset Wiltsire Avon & Gloucestershire
South West Children’s Cancer & Leukaemia
Research Network

3. NIHR CRN – what does it do?
Infrastructure that allows high-quality clinical research to take place in the NHS
Help researchers to set up clinical studies quickly and effectively
Support the life-sciences industry to deliver their research programmes in the NHS
Provide health professionals with research training
Work with patients to ensure their needs are at the very centre of all research activity.

4. NIHR CRN High Level Objectives
Increase number of participants into NIHR CRN portfolio studies
650,000 in England
21,905 in West of England
Increase the number of studies that deliver to time and target
Target 80%
Increase number of commercial studies delivered through network
650 new studies this year
75% of all commercial studies
Reduce NHS study set up times
Reduce time taken to recruit first participant

5. Local Clinical Research Networks
Translation of national objectives for clinical research
Oversight of research activity within the geography of CRN - West of England in terms of:
Portfolio
Balance, new studies, feasibility, set up, industry trials
Performance
Support, network wide solutions, targets
People
Patient involvement, staff skill mix & flexibility, training, resources

6. 30 Clinical Specialties Ageing Anaesthetics & pain Cancer
Cardiovascular
Children
Critical Care
Dementia & Neurodegenerative
Dermatology
Diabetes
ENT
Gastroenterology
Genetics
Haematology
Health Services
Hepatology
Infectious Diseases
Injuries & Emergencies
Mental Health
Metabolic & Endocrine
Musculoskeletal
Neurological
Opthalmology
Oral & Dental
Primary Care
Public Health
Renal
Reproductive Health
Respiratory
Stroke
Surgery

7. Including lymphoma

8. Local CRN sub specialty leads
NCRI Clinical Studies Groups
NIHR CRN cancer leadership

9. National Clinical Studies Groups PPI Psychosocial & Survivorship
Imaging Adv. panel
Breast Cancer
CSG
Brain Tumours
CSG
Lung Cancer
CSG
Palliative & Supportive
Care
Head & Neck
CSG
Biomarkers Adv. panel
Upper GI Cancer
CSG
Consumer Liaison Group
Sarcoma
CSG
PPI
Colorectal Cancer
CSG
Melanoma
CSG
Kidney Cancer
CSG
Primary
Care
Lymphoma
CSG
Bladder Cancer
CSG
Screening, Prevention & Early Diagnosis
Haematol.
CSG
Testis Cancer
CSG
Prostate Cancer
CSG
Gynae Cancer
CSG
Children’s Cancer & Leukaemia
Teenage &
Young Adult
CTRad (Radiotherapy)

10. Cancer sub specialty lead role
Communicate and collaborate with clinical colleagues across the network re the portfolio of studies in their sub specialty
Action plan in place to increase access to research
Mapping portfolio across the network
Shared portfolio of studies
Improve referral pathways for research
Encourage more referral for research
Consider economies of scale for rare disease studies
Network wide planning for EOIs
Support and encourage teams to meet study targets

11. NIHR CRN Objectives for cancer
Recruit 20% of cancer incidence
West of England 1,909
Recruit 7.5% of cancer incidence into interventional studies
716
Include challenging studies
Cancer surgery – 4 recruits per 100,000 population
Radiotherapy – 6 recruits per 100,000 population
Rare cancers (<6 per 100,000) – 12 recruits per 100,000 population
Children & young people – 3 per 100,000 population
Teenagers & young adults – record number of year olds participating in research

14. Open studies in SWAG - Bladder
Project Title
Chief Investigator
Project type
Site parent organisation
Principal Investigator
BRAG rating
Project site planned recruitment end date
Recruited (total)
Project site target participants
WO MPDL3280A in muscle invasive bladder cancer
Birtle Registrar, Dr Alison
Commercial portfolio
University Hospitals Bristol NHS Foundation Trust
Bahl, Dr Amit
01/10/2017 5
RAIDER
Huddart, Prof Robert
Non-commercial portfolio
Gloucestershire Hospitals NHS Foundation Trust
Jenkins, Dr Peter
01/03/2018 12
POUT
Birtle, Alison
Great Western Hospitals NHS Foundation Trust
Khan, Dr Omar
31/03/2019 1 3
North Bristol NHS Trust
Keeley, Mr Francis
31/12/2016 6 7
30/06/2017 2 10
JAVA-P
01/08/2020 4
Hyperthermia for Intermediate risk bladder cancer (HIVEC-II)
Royal United Hospitals Bath NHS Foundation Trust
Phull, Mr Jaspal
30/09/2017 8
CALIBER
Mostafid, Mr Hugh
Davenport, Miss Kim
01/06/2018 30
BRAG
Open studies
Black
Study not reported recruitment or study has not recruited
Red
% Recruitment is more than 30 behind % time elapsed, i.e. Difference < -30
Amber
% Recruitment is less than 30 behind % elapsed time but more than 0 behind % elapsed time, i.e. -30 < Difference < 0
Green
% Recruitment is equal to or greater than % elapsed time, i.e. Difference >= 0
Grey
Unable to calculate RAG due to record missing at least one data point

15. Open studies in SWAG - Prostate
Project Title
Chief Investigator
Project type
Site parent organisation
Principal Investigator
BRAG rating
Project site planned recruitment end date
Recruited (total)
Project site target participants
VIABLE
Pandha, Prof Hardev
Commercial portfolio
University Hospitals Bristol NHS Foundation Trust
Bahl, Dr Amit
16/10/2016 12 6
UK Genetic Prostate Cancer Study
Eeles, Prof Rosalind
Non-commercial portfolio
Gloucestershire Hospitals NHS Foundation Trust
Cook, Dr Audrey
31/12/2017
117 56
Great Western Hospitals NHS Foundation Trust
Cole, Dr David 31 10
North Bristol NHS Trust
Persad, Mr Rajendra AR
224
200
Royal United Hospitals Bath NHS Foundation Trust
Newman, Dr Hugh
131 20 51
Weston Area Health NHS Trust
Hilman, Dr Serena 26
True NTH UK Post Surgical Follow Up
Moore, Mrs Caroline M
Koupparis, Mr Anthony
31/03/2017 50
Stampede
McNicholas, Dr James
Bowen, Dr Jo
31/12/2020 48 14
Khan, Dr Omar 46 5
Frim, Dr Olivera
30/09/2015 71
02/02/2018 93 42
31/12/2016 18 4

16. Site parent organisation Principal Investigator BRAG rating
Project Title
Chief Investigator
Project type
Site parent organisation
Principal Investigator
BRAG rating
Project site planned recruitment end date
Recruited (total)
Project site target participants
SAPROCAN: Saracatnib and docetaxel in met, cast-ref prostate cancer
Jones, Dr Robert
Non-commercial portfolio
University Hospitals Bristol NHS Foundation Trust
Bahl, Dr Amit
01/09/2019 13 8
RADICALS (MRC PR10)
Parker, Dr Christopher
Gloucestershire Hospitals NHS Foundation Trust
Bowen, Dr Jo
30/06/2015 16 26
Great Western Hospitals NHS Foundation Trust
Khan, Dr Omar
31/12/2016 10 2
North Bristol NHS Trust
Persad, Mr Rajendra AR 40 88
Royal United Hospitals Bath NHS Foundation Trust
Frim, Dr Olivera 33
24/07/2018 27 20
Weston Area Health NHS Trust
Hilman, Dr Serena
03/05/2013 23 12
PROMPTS
Dearnaley, Prof David
31/12/2017
31/07/2015 5
ProCAID
Crabb, Dr Simon
Kehagioglou , Dr Penny
29/12/2017
PATCH
ABEL, Prof Paul
McFarlane, Mr Jonathan
01/09/2017 6
30/06/2018

17. Site parent organisation Principal Investigator BRAG rating
Project Title
Chief Investigator
Project type
Site parent organisation
Principal Investigator
BRAG rating
Project site planned recruitment end date
Recruited (total)
Project site target participants
IMPACT
Eeles, Prof Rosalind
Non-commercial portfolio
University Hospitals Bristol NHS Foundation Trust
Donaldson, Dr Alan
31/12/2016 2 20
ENZARAD
Hughes, Dr Simon
Royal United Hospitals Bath NHS Foundation Trust
Beresford, Dr Mark
13/07/2020 1 10
ENZAMET
Chowdhury, Dr Simon
Great Western Hospitals NHS Foundation Trust
Khan, Dr Omar
01/04/2017 6
CANC PREMISE
Robinson, Dr Angus
Commercial portfolio
30/06/2018 11
Weston Area Health NHS Trust
Hilman, Dr Serena
31/10/2016
ATLAS: JNJ (ARN509)
Bahl, Dr Amit
01/04/2019
ARAMIS
Birtle, Alison
30/06/2020 4

18. Open studies in SWAG - Renal
Project Title
Chief Investigator
Project type
Primary Clinical Studies Group
Site parent organisation
Principal Investigator
BRAG rating
Project site planned recruitment end date
Recruited (total)
Project site target participants
STAR Standard vs Modified Drug Therapy in Renal Cancer
Brown, Dr Janet
Non-commercial portfolio
Renal
Gloucestershire Hospitals NHS Foundation Trust
Farrugia, Dr David
01/05/2017 10 16
Great Western Hospitals NHS Foundation Trust
Khan, Dr Omar
31/05/2017 7 8
Royal United Hospitals Bath NHS Foundation Trust
Beresford, Dr Mark
30/05/2017 12 5
Pazopanib in patients with renal cancer (PaZ02)
Porfiri, E
30/06/2016 11 6
University Hospitals Bristol NHS Foundation Trust
Bahl, Dr Amit
31/08/2016 2
A-PREDICT
Larkin, Dr James
31/12/2016
No studies currently open for Testis cancer

19. Studies in set up - Renal
CANC – 3263 ADONIS
In set up at Royal United Hospitals Bath NHS Foundation Trust, PI Dr Mark Beresford.

20. Useful links https://www.crn.nihr.ac.uk/
National and local network information including training programmes templates, tools, contacts, videos etc
Open data platform. Look at performance across whole CRN including all specialty areas
/csg.ncri.org.uk/portfolio/portfolio-maps/
View current national portfolio of open, closed and ‘in set up’ cancer studies
See where a study is open across the country
Search for a study to fit criteria. Good for horizon scanning, eligibility criteria

21. Contacts Research Delivery Manager – maxine.taylor@nihr.ac.uk
Cancer portfolio facilitator –