1. Fig. S1
+ leu
- leu A 5 * 4 3
Serum TSH (ng/ml) 2 1

2. * * * * - - Fig. S2 A B + + + leu - leu 4 26 3 24 #
Average Body Weight (g) *
Average Food Intake (g) 2 * 22 1 20 - + - +
TRH Ab
TRH Ab

3. * Fig. S3 A B - leu/ - TRH Ab/ - T3 - leu/ + TRH Ab/ - T34 26 * # 25 3 #
Average Body Weight (g) 24
Average Food Intake (g) 2 23 1 22 21

4. * * * * - - Fig. S4 A B + + + leu - leu 4 26 # 3 24
Average Body Weight (g) *
Average Food Intake (g) 2 22 1 20 - + - +
Ad-shCREB
Ad-shCREB

5. * Fig. S5 A B - leu/ - shCREB/ - TRH - leu/ + shCREB/ - TRH
3.0 30 * #
2.0 20
Average Food Intake (g)
Average Body Weight (g)
1.0 10