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AIDSACTIONBALTIMORE PREP UP TOWN HALL

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Presentation on theme: "AIDSACTIONBALTIMORE PREP UP TOWN HALL"— Presentation transcript:

1 AIDSACTIONBALTIMORE PREP UP TOWN HALL
PreP and Prevention IAC 2018 Update Lynda Dee September 26, 2018

2 PrEP UP Town Hall Meeting
CDC: HIV Transmission Statistics CDC: Impact of PrEP on HIV Diagnoses 2012 to 2016 2017 TASP: Transmission in Undetectable MSM Couples PARTNER 2 Study: U=U in MSM Couples Biologic & Behavioral Risk: Before, During and After PrEP PREPARE Study: STI Incidence on PrEP vs. No PrEP Adolescents: Use of PrEP New Data: HIV Prevention Strategies

3 PrEP UP Town Hall Meeting
CDC HIV Transmission Statistics 1 in 49 in Maryland 1 in 20 in Black Men in the US 1 in 2 in Black MSM in the US

4 PrEP UP Town Hall Meeting
CDC: PrEP Impact on HIV Diagnoses HIV diagnosis declined 18% from 2008 to 2015 There will still be approx 40,000 diagnoses each year Reasons for possible diagnosis decline: Lower frequency of testing Lower sexual and needle sharing behavior Higher viral suppression in people with HIV Higher PrEP uptake for those at risk

5 PrEP UP Town Hall Meeting
CDC: PrEP Impact on HIV Diagnoses HIV testing and risk behaviors have not decreased Whether lower viral suppression and PrEP use accounts for decreased diagnoses is unknown PrEP use increased in the US from 2012 to 2015, independent of higher viral suppression US states should to take steps to increase both PrEP use and viral suppression These associations need to be studied in counties

6 PrEP UP Town Hall Meeting
Undetectable VL & HIV Transmission in Gay Couples Opposites Attract: (TASP) Observational study in 3 countries 12,000 condom free male anal sex acts in 3/4 of couples 343 discordant couples, (one positive and one negative) Some men had other partners

7 PrEP UP Town Hall Meeting
Undetectable VL & HIV Transmission in Gay Couples No infections in HIV partner by HIV+ partner PARTNER 1 + Opposites Attract = 34,911 condomless anal sex acts Condomless sex, with HIV+ partner who is undetectable = safe sex CAUTION: VL remains detectable in the first months after ARVs

8 PrEP UP Town Hall Meeting
Undetectable VL & HIV Transmission in Gay Couples PARTNER 1 study in heterosexual and gay couples PARTNER 2 study: Gay couples only: HIV+ partner is on effective ART PARTNER 2 enrolled 972 gay couples (480 couples from PARTNER 1) Median condomless sex 43 times per year 76,991 sex acts without condoms during the follow-up period

9 PrEP UP Town Hall Meeting
Undetectable VL & HIV Transmission in Gay Couples HIV was phylogenetically tested to determine origin of infection Some HIV transmission in HIV-s, but not from their HIV+ partners HIV transmission came from another person, not their partner There was zero transmission within couple infections Confirms PARTNER 1 and TASP: A couple would need to have unprotected sex for 400 years to be at risk for HIV infection

10 PrEP UP Town Hall Meeting
PrEP Use Rising, STI Remaining Stable (SUNY) PrEP use rose from 3% to 21% in US MSM Reviewed condom use before, during and after PrEP and the STI rate to determine if STI rate would increase significantly 313 adult MSM who used PrEP during at least 1 visit Tracked condomless anal sex with a casual partner, HIV+ or status unknown partner and the probability of a rectal STI diagnosis 50% white, 2/3 had full time jobs, 50% in relationships

11 PrEP UP Town Hall Meeting
PrEP Use Rising, STI Remaining Stable (SUNY) Average condomless sex rose from 2.79 to 7.13 during PrEP use, and fell to fell to 2.09 after PrEP use stopped Average number of receptive condomless sex acts from to , then dropped to after PrEP use stopped Probability of rectal STIs rose insignificantly while on PrEP, then dropped significantly after PrEP use stopped Condomless sex acts did increase, but STI rate remained stable PrEP benefit is far greater than slight risk of STI increases while on PrEP; and STI risk decreased after PrEP use stopped

12 PrEP UP Town Hall Meeting
PREPARE Study: STI Incidence on PrEP vs. No PrEP Many young adult males do not seek healthcare Regular PrEP visits = better health care practices Healthcare utilization review through health records in Southern CA Young males (18-34) from 7-14 to 4-16, before and after PrEP use 304 PrEP users and 4,495 MSM with no PrEP use, 273,050 not MSM

13 PrEP UP Town Hall Meeting
PREPARE Study: STI Incidence on PrEP vs. No PrEP PrEP users were older (27-34 vs ), and had more care, including more ER, primary, psychiatric and other specialty visits PrEP users had more mental health diagnoses HPV/HBV vaccinations: Low in all groups, but higher with PrEP use Higher STI and hepatitis testing in PrEP users Higher STIs and mental disorders in the PrEP group, but better primary and preventive care as well as STI screening

14 PrEP UP Town Hall Meeting
PrEP Use in US Adolescents 15.4% PrEP use in adolescents under 24 years old 1.5% PrEP use in adolescents under 18 years old In adolescents under 18, PrEP usage was 83.5% female PrEP use in years is 84.2% male Recent FDA indication change may improve adolescent access Important unmet need: Improve PrEP awareness and engagement

15 PrEP UP Town Hall Meeting
New HIV Prevention Strategies (2017 IAS Meeting) Long-Acting Cabotegravir (CAB): IM injection/8wks Long-Acting Rilpivirine: Development Stopped Long-Acting Oral MK-8591: Oral every 30 days?

16 PrEP UP Town Hall Meeting
New Prevention Strategies Broadly Neutralizing Antibodies (nNAbs) Alternative to vaccine approach Single IV infusion combo results in monkeys Single IV infusion plus SubQ results in monkeys

17 PrEP UP Town Hall Meeting
New Prevention Strategies: (bNAbs) IV 3BNC117 + LS dmAB (11 to 23 wk infection delay) IV LS dmAb (18 to 37 wk infection delay) IV BNC117 + LS dmAB (Subq) (20 weeks) Could translate to annual or semi-annual regimens

18 PrEP UP Town Hall Meeting
Next Town Hall Meeting Wednesday, November 28, 2018 Time 6:30 to 8:00 PM Place Waxter Center

19 PrEP UP Town Hall Meeting
THANK YOU Gilead Sciences Baltimore City Health Department

20 PrEP UP Town Hall Meeting
THANK YOU Johns Hopkins Reach Initiative Chase Brexton Health Care Center for Black Equity-Baltimore GLCCB Jacques Initiative Total Health Care PrEP UP: Falina Chanel, Alvin Moody, Jeffrey Grabelle, Jay Mangum

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