1. ADRINERGIC DRUGS By
Dr. Mirza Shahed Baig

2. NERVOUS SYSTEM

4. Neurotransmitters in Adrenergic System

5. Biosynthesis of Neurotransmitters

6. Storage, Metabolism, & Release

7. Metabolism of Neurotransmitters

8. Adrenergic Receptors

9. Types of Adrenergic Receptors

10. Adrenergic receptors are G-Protein Couple Receptors (GPCRs)

11.  α1 couples to Gq, which results in increased intracellular Ca2+and subsequent smooth muscle contraction. 
α2, on the other hand, couples to Gi, which causes a decrease in neurotransmitter release, as well as a decrease of cAMP activity resulting in smooth muscle contraction.
β receptors couple to Gs, and increases intracellular cAMPactivity, resulting in e.g. heart muscle contraction, smooth muscle relaxation and glycogenolysis.

12. Typical Location in Body

13. Typical effects produce by Neurotransmitter on different receptors

14. Possible site of action of adrenergic drugs

16. Adrenergic Agonists

17. Chemistry of Direct Acting Adrenergic Agonists

18. Some examples of agonists

19. Classification of Adrenergic Agonists

20. Chemistry of β – Blockers

21. Adrenergic Antagonists