1. SYMPATHOMIMETICS Classification: A- According to the source:
Natural; NE, EP, DA
Synthetic; isoproternol, ephedrine, amphetamine
B- chemically:
Catecholamines; NE, EP, DA and isoproternol
Non catecholamines; ephedrine, amphetamine, tyramine

2. IN DIRECT(MIXED) ACTING drugs
α receptor
Agonist
Selective α2: clonidine
Non selective α 1, α2:
Phenylephrine
Antagonist
(blockers)
Selective:
α1=parzosin,
Tamsulosin
α2= yohimbine
Non selctive α 1, α2:
Phenoxybenzamine
phentolamine
β receptor Agonist Antagonist (blockers)
α &β
Receptor
Agonist
Antagonist
(blockers)
D receptor
Agonist
IN DIRECT(MIXED) ACTING drugs
Agonist
( adrenergic)
Increase release of agonist(NE)
Work on receptor as agonist (NE)
Antagonist
(anitadrenergic)
False NE
>illegal

3. Non Selective α receptor and blockersα1 α2
Found in
Agonist (receptors )
Antagonist (blockers)
smooth muscle of many organs
( B.Vs)
vasoconstriction
increase arterial resistance
Selective α1 blockers:
(prazosin,Tamsulosin):
Vasodilatation
Hypotension
GIT
Decrease motility relaxation
Liver
glycogenlysis
Eye
Mydriasis
increases the outflow of aqueous humor from the eye
Found in
Agonist (receptors )
Antagonist (blockers)
smooth muscle of many organs
( B.Vs)
Selective α2receptors :
(clonidine)
found postsynaptically :
As α1action =
Vasoconstriction
found presynaptically: platelets
aggregation
Blocker Selective α2 : (yohimbine)
vasodilatation
Brain(CNS)
Found presynaptically:
( stop release of
nor adrenaline)
Inhibition sympathetic effect
Blocker Selective α2 (yohimbine)= human being :P
Increase
( nor adrenaline release )
and cause sympathomimetic effect
Pancreas
inhibition Insulin secretion
Kidney
inhibition Renin secretion
Non Selective α receptor and blockers
Non selective α- receptors:
Example: Phenylephrine
The bladder base, urethral sphincter and prostate contain α receptors that mediate contraction and therefore promote urinary continence.
Non selective α-blockers:
Examples: phenoxybenzamine, phentolamine
Vasodilatation
Reduce blood pressure

4. Selective &Non Selective β blockersβ1 β2
Found in
Agonist (receptors )
Respiratory- Lung-
bronchodilation
peripheral vasodilatation
visceral smooth muscle=relaxation
skeletal muscle =tremor
uterus
relaxation that might be useful during pregnancy.
(premature labor)
LIVER
enhances glycogenolysis = increased glucose release into the circulation
Mainly By β2
Found in
Agonist (receptors )
Antagonist (blockers)
Heart
Increase: HR
(+ve chronotropic effects).
cardiac out put (Contractility )=
(+ve inotropic effects)
selective: β in general
( not β1 )
Examples: Atenolol, metoprolol
Reduce :
HR (-ve chronotropic effects)
force of heart contraction
(-ve ionotropic effects)
Kidney
Renin secretion is stimulated by β1
Selective &Non Selective β blockers
Selective
Repeated !!
Selective β-blockers :
Examples: Atenolol, metoprolol
Reduce HR (-ve chronotropic)
Reduce force of heart contraction (-ve ionotropic)
Non Selective β-blockers :
Example: Propranolol, labetalol
decreases the production of the aqueous humor. These effects are beneficial in treatment of glaucoma.
Effect on
potassium
promotes uptake of potassium into cells, leading to fall in extracellular potassium..
Carbohydrates metabolism
in muscle and liver is enhanced

5. Activation of β3 receptors in fat cells leads to increased lipolysis.
Pancreas
Insulin secretion is stimulated by β
inhibition Insulin secretion α2
Kidney
Renin secretion is stimulated by β1
inhibition Renin secretion α2