Presentation is loading. Please wait.

Presentation is loading. Please wait.

Tiotropium add-on therapy improves lung function in children with symptomatic moderate asthma  Christian Vogelberg, MD, PhD, Michael Engel, MD, István.

Published byRenate Finstad Modified over 5 years ago

Similar presentations

Presentation on theme: "Tiotropium add-on therapy improves lung function in children with symptomatic moderate asthma  Christian Vogelberg, MD, PhD, Michael Engel, MD, István."— Presentation transcript:

1 Tiotropium add-on therapy improves lung function in children with symptomatic moderate asthma 
Christian Vogelberg, MD, PhD, Michael Engel, MD, István Laki, MD, Jonathan A. Bernstein, MD, Olaf Schmidt, MD, Georges El Azzi, MD, Petra Moroni-Zentgraf, MD, Ralf Sigmund, Dipl-Math Oec, Eckard Hamelmann, MD, PhD  The Journal of Allergy and Clinical Immunology: In Practice  Volume 6, Issue 6, Pages e9 (November 2018) DOI: /j.jaip Copyright © 2018 The Authors Terms and Conditions

2 Figure E1 Study design. ICS, Inhaled corticosteroids; LTRA, leukotriene receptor antagonist. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, e9DOI: ( /j.jaip ) Copyright © 2018 The Authors Terms and Conditions

3 Figure E2 Patient disposition CONSORT diagram.
The Journal of Allergy and Clinical Immunology: In Practice 2018 6, e9DOI: ( /j.jaip ) Copyright © 2018 The Authors Terms and Conditions

4 Figure E3 A, Peak FEV1(0-3h) responses at weeks 24 and 48. B, Trough FEV1 responses at weeks 12, 24, and 48. Full analysis set. Adjusted for treatment, country, visit, baseline, treatment-by-visit interaction, and baseline-by-visit interaction. Error bars are ±standard error. FEV1 common baseline mean ± standard deviation = 1629 ± 393 mL. FEV1, Forced expiratory volume in 1 second; FEV1(0-3h), forced expiratory volume in 1 second within 3 hours after dosing. *P < .05. **P ≤ .001 versus placebo Respimat. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, e9DOI: ( /j.jaip ) Copyright © 2018 The Authors Terms and Conditions

5 Figure E4 FEF25-75% responses at weeks 12, 24, and 48. Full analysis set. Adjusted for treatment, country, visit, baseline, treatment-by-visit interaction, and baseline-by-visit interaction. Error bars are ±standard error. FEF25-75% common baseline mean ± standard deviation = 1431 ± 584 mL. FEF25-75%, Forced expiratory flow at 25% to 75% of the forced vital capacity. *P < .05. **P ≤ .001 versus placebo Respimat. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, e9DOI: ( /j.jaip ) Copyright © 2018 The Authors Terms and Conditions

Download ppt "Tiotropium add-on therapy improves lung function in children with symptomatic moderate asthma  Christian Vogelberg, MD, PhD, Michael Engel, MD, István."

Similar presentations

Double-Blind Placebo-Controlled Trial of Dapsone in Antihistamine Refractory Chronic Idiopathic Urticaria  Matt Morgan, MD, Andrew Cooke, MD, Laura Rogers,

Double-Blind Placebo-Controlled Trial of Dapsone in Antihistamine Refractory Chronic Idiopathic Urticaria  Matt Morgan, MD, Andrew Cooke, MD, Laura Rogers,
Pinja Ilmarinen, PhD, Leena E

Pinja Ilmarinen, PhD, Leena E
Asthma Yardstick Annals of Allergy, Asthma & Immunology

Asthma Yardstick Annals of Allergy, Asthma & Immunology
Diagnostic Accuracy of Inflammatory Markers for Diagnosing Occupational Asthma  Geneviève Racine, Roberto Castano, MD, PhD, André Cartier, MD, Catherine.

Diagnostic Accuracy of Inflammatory Markers for Diagnosing Occupational Asthma  Geneviève Racine, Roberto Castano, MD, PhD, André Cartier, MD, Catherine.
The ABCs of Asthma Control

The ABCs of Asthma Control
The Role of the Primary Care Physician in Helping Adolescent and Adult Patients Improve Asthma Control  Barbara P. Yawn, MD, MSc  Mayo Clinic Proceedings 

The Role of the Primary Care Physician in Helping Adolescent and Adult Patients Improve Asthma Control  Barbara P. Yawn, MD, MSc  Mayo Clinic Proceedings 
Comparative efficacy and anti-inflammatory profile of once-daily therapy with leukotriene antagonist or low-dose inhaled corticosteroid in patients with.

Comparative efficacy and anti-inflammatory profile of once-daily therapy with leukotriene antagonist or low-dose inhaled corticosteroid in patients with.
Similar Efficacy with Omalizumab in Chronic Idiopathic/Spontaneous Urticaria Despite Different Background Therapy  Thomas B. Casale, MD, Jonathan A. Bernstein,

Similar Efficacy with Omalizumab in Chronic Idiopathic/Spontaneous Urticaria Despite Different Background Therapy  Thomas B. Casale, MD, Jonathan A. Bernstein,
Long-Term Inhaled Corticosteroid Adherence in Asthma Patients with Short-Term Adherence  Laurent Laforest, MD, PhD, Manon Belhassen, MSc, Gilles Devouassoux,

Long-Term Inhaled Corticosteroid Adherence in Asthma Patients with Short-Term Adherence  Laurent Laforest, MD, PhD, Manon Belhassen, MSc, Gilles Devouassoux,
Tiotropium improves lung function in patients with severe uncontrolled asthma: A randomized controlled trial  Huib A.M. Kerstjens, MD, PhD, Bernd Disse,

Tiotropium improves lung function in patients with severe uncontrolled asthma: A randomized controlled trial  Huib A.M. Kerstjens, MD, PhD, Bernd Disse,
Effect of montelukast for treatment of asthma in cigarette smokers

Effect of montelukast for treatment of asthma in cigarette smokers
Shyam Joshi, MD, David A. Khan, MD 

Shyam Joshi, MD, David A. Khan, MD 
Jennie Gane, MBChB (Hons), MSc, Roger Buckley, BM BCh, MA, FRCS 

Jennie Gane, MBChB (Hons), MSc, Roger Buckley, BM BCh, MA, FRCS 
A phase III randomized controlled trial of tiotropium add-on therapy in children with severe symptomatic asthma  Stanley J. Szefler, MD, Kevin Murphy,

A phase III randomized controlled trial of tiotropium add-on therapy in children with severe symptomatic asthma  Stanley J. Szefler, MD, Kevin Murphy,
The Effect of Tiotropium in Symptomatic Asthma Despite Low- to Medium-Dose Inhaled Corticosteroids: A Randomized Controlled Trial  Pierluigi Paggiaro,

The Effect of Tiotropium in Symptomatic Asthma Despite Low- to Medium-Dose Inhaled Corticosteroids: A Randomized Controlled Trial  Pierluigi Paggiaro,
Desensitization to Chemotherapeutic Agents

Desensitization to Chemotherapeutic Agents
Intramuscular Versus Intravenous Immunoglobulin Replacement Therapy and Measurement of Immunoglobulin Levels During Immunoglobulin Replacement Therapy 

Intramuscular Versus Intravenous Immunoglobulin Replacement Therapy and Measurement of Immunoglobulin Levels During Immunoglobulin Replacement Therapy 
Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-to-severe asthma  Eric D. Bateman, MD, Udo-Michael.

Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-to-severe asthma  Eric D. Bateman, MD, Udo-Michael.
Felix Ratjen, Paul Koker, David E

Felix Ratjen, Paul Koker, David E
Practice Notes from the AAAI

Practice Notes from the AAAI

Similar presentations

Ads by Google