1. Cluster Analysis on Longitudinal Data of Patients with Adult-Onset Asthma 
Pinja Ilmarinen, PhD, Leena E. Tuomisto, MD, PhD, Onni Niemelä, MD, PhD, Minna Tommola, MD, Jussi Haanpää, MSc, Hannu Kankaanranta, MD, PhD 
The Journal of Allergy and Clinical Immunology: In Practice 
Volume 5, Issue 4, Pages e3 (July 2017)
DOI: /j.jaip
Copyright © 2017 The Authors Terms and Conditions

2. Figure 1 Flow chart of the study.
The Journal of Allergy and Clinical Immunology: In Practice 2017 5, e3DOI: ( /j.jaip )
Copyright © 2017 The Authors Terms and Conditions

3. Figure 2
Basic characteristics of clusters. In A-F, C1 to C5 refer to the cluster numbers. Overall P values are shown. In B and F, the red lines shown are means. In D, means are shown. BMI, Body mass index; DG, diagnosis.
The Journal of Allergy and Clinical Immunology: In Practice 2017 5, e3DOI: ( /j.jaip )
Copyright © 2017 The Authors Terms and Conditions

4. Figure 3
Asthma-related use of health care and use of oral steroids during the follow-up period. In A, shown is the number of asthma-related visits to health care during the 12-year follow-up period. The red lines shown are means. In B, shown is the proportion of patients with at least one hospitalization during the 12-year follow-up period. In C, shown is self-reported oral steroid use within two years before the 12-year follow-up visit. In A-C, C1-C5 refers to the cluster number.
The Journal of Allergy and Clinical Immunology: In Practice 2017 5, e3DOI: ( /j.jaip )
Copyright © 2017 The Authors Terms and Conditions

5. Figure 4
Longitudinal changes in lung function, blood eosinophils, and symptoms (AQ20) in 5 clusters of adult-onset asthma. In A: *P < .05, **P < .01, and ***P < .001, at left side ΔFEV1 from diagnosis to Max0-2.5, and at right side ΔFEV1 from Max0-2.5 to 12-y follow-up visit within the cluster. In B and C: *P < .05, **P < .01, and ***P < .001 of ΔFEV1 from diagnosis to follow-up visit within each cluster.
The Journal of Allergy and Clinical Immunology: In Practice 2017 5, e3DOI: ( /j.jaip )
Copyright © 2017 The Authors Terms and Conditions