1. DEVELOPMENT OF THE CNS II
Key points
Factors that influence cell lineage and differentiation
Migration of cells
Growth of processes and recognition of target cells
Maps and polarity gradients
Regressive events including cell death and pruning of axons
Reading – NB these texts mostly describe embryology and do not discuss cellular developmental events
Nolte (4th Ed), pgs 36-49
Fitzgerald, pgs 1-7
Crossman and Neary, pgs 3-8
Kiernan, pgs 4-11, 39-40

2. Specification of the neural tube and neural crest
22-23 days

3. Cell lineage and differentiation
Stem cells
What controls the differentiation of stem cells into neurons and glia?
What are the lineage relationships between different classes of neurons and glia?
When does a cell become committed to a particular phenotype?

4. Radial migration in the developing telencephalon

5. Inside-out sequence of birthdays
Migration
Inside-out sequence of birthdays

7. Axon outgrowth and target recognition
Growth cones
Substrate guidance
Polarity markers and formation of specific connections

8. Guidance of growing axons
Diffusible and contact mediated factors – attraction and repulsion

11. Regressive events Cell death Growth or trophic factors
Elimination of axons
Loss of synapses

12. Retrograde influences on neuronal viability and phenotype

15. Dendritic spines and synaptic density – changes with age
HUMAN
Dendritic spines and synaptic density – changes with age