1. ADVANCED Biomaterials
University Politehnica of Bucharest
Faculty of Material Science and Engineering
Biomaterials & Biointerfaces Group
ADVANCED Biomaterials
- And their importance to medical APPLICATIONS
“BIONECA - Biomaterials and advanced physical techniques for regenerative cardiology and neurology”
Central Library of University POLITEHNICA of Bucharest, Romania, October 2017

2. Faculty of Material Science and Engineering
University Politehnica of Bucharest
Faculty of Material Science and Engineering
Biomaterials & Biointerfaces Group

3. Implants-tissue interfaces
LAFIN Laboratory Some Experimental Results
Implants-tissue interfaces

4. LAFIN Laboratory Some Experimental Results
Scaffolds characterization
SEM results
on collagen scaffolds

5. New metallic biomaterials
Biodegradable magnesium alloys
Biodegradable iron based alloys
porous tantalum
Zr-2.5Nb
Ti-Zr alloy
NANOMATERIALS

6. MAGnesium alloys Pathophysiology/toxicology Element Magnesium
Normal blood serum level 0.73–1.06 mmol/L
Influences growth factor effectiveness
Co-regulator of energy metabolism, cell proliferation, protein synthesis, onset of DNA synthesis
Regulator of more than 350 proteins
Stabilizer of DNA and RNA
Long-term influence on cellular reactions
Calcium
Normal serum level 0.919–0.993 mg/L
Most abundant mineral in the human body (1–1.1 kg)
Mainly stored in bone, teeth
Is tightly regulated by homeostasis of skeletal, renal and intestinal mechanism
Zinc
Normal blood serum level 12.4–17.4 lmol/L
Trace element
Essential for the immune system
Co-factor for specific enzymes in bone and cartilage [98,99]
Neurotoxic at higher concentrations
Zirconium
exhibits good biocompatibility and osseointegration both in vitro and in vivo (surpassing even titanium)
Divalent Cation Metabolism: Magnesium, James T. McCarthy, Rajiv Kumar

7. Immersion tests of experimental magnesium alloys
7 days
14 days
30 days A B C
PBS (A)
HBSS (B)
DMEM +10%FBS (C)
Surface macro-morphologies of MgCa0.8 after 7 , 14 and 30 days in:

8. Conclusions New metallic biomaterials
Surface modifications of the metallic biomaterials
New processing technologies for metals
Scaffolds vs. implants
Interactions cells / drugs / biomaterials

9. Acknowledgement