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Faraz Kerendi, MD, Paul M. Kirshbom, MD, Michael E

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Presentation on theme: "Faraz Kerendi, MD, Paul M. Kirshbom, MD, Michael E"— Presentation transcript:

1 Cobalt Chloride Pretreatment Attenuates Myocardial Apoptosis After Hypothermic Circulatory Arrest 
Faraz Kerendi, MD, Paul M. Kirshbom, MD, Michael E. Halkos, MD, Ning-Ping Wang, PhD, Hajime Kin, MD, Rong Jiang, PhD, Zhi-Qing Zhao, PhD, Kirk R. Kanter, MD, Robert A. Guyton, MD, Jakob Vinten-Johansen, PhD  The Annals of Thoracic Surgery  Volume 81, Issue 6, Pages (June 2006) DOI: /j.athoracsur Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Photomicrographs (×40 magnification) demonstrating subendocardial apoptosis (red-stained nuclei by TUNEL assay) after 110 minutes of circulatory arrest in (A) control animals, compared with animals preconditioned with (B) hypoxia, (C) deferoxamine, or (D) cobalt chloride. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Percentage of apoptotic nuclei in subendocardium of control animals compared with animals preconditioned with hypoxia, deferoxamine (DFX), or cobalt chloride after 110 minutes of circulatory arrest. (*Indicates p = 0.042; error bars represent SD.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Representative figure showing DNA laddering in subendocardial specimens of animals subjected to 110 minutes of circulatory arrest after preconditioning with cobalt chloride, deferoxamine (DFX), or hypoxia versus controls. (MW = molecular weight marker.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Left ventricular ratio of phosphorylated Akt (p-Akt) to unphosphorylated Akt by Western blot assay in control animals compared with animals preconditioned with hypoxia, deferoxamine (DFX), or cobalt chloride after 110 minutes of circulatory arrest. (*Indicates p < 0.001; error bars represent SD.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Left ventricular levels of (A) Bcl-2, (B) Bax, and (C) Bcl-2/Bax ratio by Western blot assay in control animals compared with animals preconditioned with cobalt chloride after 110 minutes of circulatory arrest. (*Indicates p < 0.001, **Indicates p = 0.004; error bars represent SD.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

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