1. Immune features from Model 3 that associate with and predict the HAI response to TIV. The cross‐validated area under the ROC curve (cvAUROC) for Model 3 is depicted in A and the selected immune features that associate with and predict the HAI response to TIV in B. mod_047, gene module APO; CD8/U/STAT1, pSTAT1 in unstimulated CD8+ T cells; CD4.CM, central‐memory CD4+ T cells; CD8.EM, effector‐memory CD8+ T cells; mod_085, gene module PROL; pre‐GMT, geometric mean titer for all three virus strains; CD8.NA, naive CD8 T cell frequency; mod_054, gene module 54 (cell death by apoptosis; P<0.01); mod_034, gene module 34 (cell‐to‐cell signaling and interaction; P<0.01); mod_043, gene module 43 (RNA post‐transcriptional modification; P<0.01); CD8 CD28‐, CD8+ CD28− cell frequency; NK cells, NK cell frequency; mod_079 and mod_092, gene modules 79 and 92 (metabolism of carbohydrates (P<0.01)).
Immune features from Model 3 that associate with and predict the HAI response to TIV. The cross‐validated area under the ROC curve (cvAUROC) for Model 3 is depicted in A and the selected immune features that associate with and predict the HAI response to TIV in B. mod_047, gene module APO; CD8/U/STAT1, pSTAT1 in unstimulated CD8+ T cells; CD4.CM, central‐memory CD4+ T cells; CD8.EM, effector‐memory CD8+ T cells; mod_085, gene module PROL; pre‐GMT, geometric mean titer for all three virus strains; CD8.NA, naive CD8 T cell frequency; mod_054, gene module 54 (cell death by apoptosis; P<0.01); mod_034, gene module 34 (cell‐to‐cell signaling and interaction; P<0.01); mod_043, gene module 43 (RNA post‐transcriptional modification; P<0.01); CD8 CD28‐, CD8+ CD28− cell frequency; NK cells, NK cell frequency; mod_079 and mod_092, gene modules 79 and 92 (metabolism of carbohydrates (P<0.01)).
David Furman et al. Mol Syst Biol 2013;9:659
© as stated in the article, figure or figure legend