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Christopher C. Miller, Christopher A

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1 Inhaled nitric oxide decreases the bacterial load in a rat model of Pseudomonas aeruginosa pneumonia 
Christopher C. Miller, Christopher A. Hergott, Marta Rohan, Kyle Arsenault-Mehta, Gerd Döring, Sanjay Mehta  Journal of Cystic Fibrosis  Volume 12, Issue 6, Pages (December 2013) DOI: /j.jcf Copyright © 2013 European Cystic Fibrosis Society. Terms and Conditions

2 Fig. 1 Effect of high-dose intermittent NO inhalation on Pseudomonas aeruginosa cell numbers in a lung infection model in rats. Solid bars represent treatment (160ppm NO for 30min every 4h) and open bars represent control (continuous room air for 12 or 24h). Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2013 European Cystic Fibrosis Society. Terms and Conditions

3 Fig. 2 Myeloperoxidase activity in infected and un-infected rats, treated with high-dose intermittent NO. The influx of neutrophils into rat lung tissues was measured in P. aeruginosa infected and uninfected (PBS) rats. Solid bars represent treatment (160ppm NO for 30min every 4h) and open bars represent control (continuous room air for 24h). ns=statistically not significant. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2013 European Cystic Fibrosis Society. Terms and Conditions

4 Fig. 3 Plasma nitrite/nitrate levels in P. aeruginosa infected rats treated with high-dose intermittent NO. Nitrite/nitrate (NOx) levels were determined in plasma samples of P. aeruginosa infected and uninfected (PBS) rats. Solid bars represent treatment (160ppm NO for 30min every 4h) and open bars represent control (continuous room air for 24h). ns=statistically not significant. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2013 European Cystic Fibrosis Society. Terms and Conditions


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