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The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa.

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Presentation on theme: "The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa."— Presentation transcript:

1 The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection — A pilot study  Marianne Skov, Tacjana Pressler, Jens Lykkesfeldt, Henrik Enghusen Poulsen, Peter Østrup Jensen, Helle Krogh Johansen, Tavs Qvist, Dorthe Kræmer, Niels Høiby, Oana Ciofu  Journal of Cystic Fibrosis  Volume 14, Issue 2, Pages (March 2015) DOI: /j.jcf Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

2 Fig. 1 Changes in the plasma levels of ascorbic acid (AA) and dehydroascorbate (DHA) at the end of the study compared to baseline in the NAC treated group (A and C) and in the control group (B and D, respectively). Significant higher plasma levels of ascorbate (p=0.037) and lower of oxidized ascorbate (p=0.004) compared to baseline were found in the NAC treated patients but not in the control group. Paired t-test was used to analyze the differences between the levels at the end of the study compared to baseline. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

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