Presentation is loading. Please wait.

Presentation is loading. Please wait.

Colorectal small cell carcinoma in ulcerative colitis with identical rare p53 gene mutation to associated adenocarcinoma and dysplasia  Hiroyuki Hayashi,

Published byTerence Cooper Modified over 5 years ago

Similar presentations

Presentation on theme: "Colorectal small cell carcinoma in ulcerative colitis with identical rare p53 gene mutation to associated adenocarcinoma and dysplasia  Hiroyuki Hayashi,"— Presentation transcript:

1 Colorectal small cell carcinoma in ulcerative colitis with identical rare p53 gene mutation to associated adenocarcinoma and dysplasia  Hiroyuki Hayashi, Yohei Miyagi, Akiko Sekiyama, Sachiko Yoshida, Sayumi Nakao, Noriko Okamoto, Kazutaka Koganei, Akira Sugita  Journal of Crohn's and Colitis  Volume 6, Issue 1, Pages (February 2012) DOI: /j.crohns Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

2 Figure 1 Rectosigmoidal area of the resected specimen. Ulcerative main tumor (x) and satellite adenocarcinomas (arrows). Journal of Crohn's and Colitis 2012 6, DOI: ( /j.crohns ) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

3 Figure 2 Main tumor consists of small cell carcinoma (left) and adenocarcinoma (right) (HE stain). Journal of Crohn's and Colitis 2012 6, DOI: ( /j.crohns ) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

4 Figure 3 Small cell carcinoma: solid sheet of small cells with hyperchromatic nuclei, finely granular chromatin and scant cytoplasm (HE stain). Journal of Crohn's and Colitis 2012 6, DOI: ( /j.crohns ) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

5 Figure 4 Small cell carcinoma: tumor cells are positive for synaptophysin immunostain. Journal of Crohn's and Colitis 2012 6, DOI: ( /j.crohns ) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

6 Figure 5 Electropherograms of TP53 mutation analysis: All lesions showed an identical somatic single nucleotide alteration of C to T transition at the codon 331. Arrows indicate mutated nucleotide in each panel. AC, adenocarcinoma; SCC, small cell carcinoma. Journal of Crohn's and Colitis 2012 6, DOI: ( /j.crohns ) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

7 Supplementary Figure S1
Microscopic view of the lesions before (left) and after (center) microdissection and the dissected cells (right): a. dysplasia, b. satellite adenocarcinoma, c. adenocarcinoma associated with small cell carcinoma, d. small cell carcinoma. Journal of Crohn's and Colitis 2012 6, DOI: ( /j.crohns ) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Download ppt "Colorectal small cell carcinoma in ulcerative colitis with identical rare p53 gene mutation to associated adenocarcinoma and dysplasia  Hiroyuki Hayashi,"

Similar presentations

Collision adenocarcinoma–carcinoid tumor of the rectum arising in ulcerative colitis  Nobuyoshi Yamazaki, Yuji Nishizawa, Motohiro Kojima, Nobuhiro Sugano,

Collision adenocarcinoma–carcinoid tumor of the rectum arising in ulcerative colitis  Nobuyoshi Yamazaki, Yuji Nishizawa, Motohiro Kojima, Nobuhiro Sugano,
Small cell neuroendocrine carcinoma of the esophagus

Small cell neuroendocrine carcinoma of the esophagus
Diffuse Type Gastric and Lobular Breast Carcinoma in a Familial Gastric Cancer Patient with an E-Cadherin Germline Mutation  Gisela Keller, Holger Vogelsang,

Diffuse Type Gastric and Lobular Breast Carcinoma in a Familial Gastric Cancer Patient with an E-Cadherin Germline Mutation  Gisela Keller, Holger Vogelsang,
High and increasing prevalence of inflammatory bowel disease in Finland with a clear North–South difference  Airi Jussila, Lauri J. Virta, Veikko Salomaa,

High and increasing prevalence of inflammatory bowel disease in Finland with a clear North–South difference  Airi Jussila, Lauri J. Virta, Veikko Salomaa,
Matthew D. Rutter, Robert H. Riddell 

Matthew D. Rutter, Robert H. Riddell 
The requirements and barriers to successful transition of adolescents with inflammatory bowel disease: Differing perceptions from a survey of adult and.

The requirements and barriers to successful transition of adolescents with inflammatory bowel disease: Differing perceptions from a survey of adult and.
Disseminated Cryptococcus neoformans infection and Crohn's disease in an immunocompetent patient  Guido Sciaudone, Gianluca Pellino, Ilaria Guadagni,

Disseminated Cryptococcus neoformans infection and Crohn's disease in an immunocompetent patient  Guido Sciaudone, Gianluca Pellino, Ilaria Guadagni,
Risk of colorectal cancer and small bowel adenocarcinoma in Crohn's disease: A population-based study from western Hungary 1977–2008  Peter Laszlo Lakatos,

Risk of colorectal cancer and small bowel adenocarcinoma in Crohn's disease: A population-based study from western Hungary 1977–2008  Peter Laszlo Lakatos,
Serta Kılınçalp, Akif Altınbaş, Ömer Başar, Murat Deveci, Osman Yüksel 

Serta Kılınçalp, Akif Altınbaş, Ömer Başar, Murat Deveci, Osman Yüksel 
Dermatological adverse reactions during anti-TNF treatments: Focus on inflammatory bowel disease  Giammarco Mocci, Manuela Marzo, Alfredo Papa, Alessandro.

Dermatological adverse reactions during anti-TNF treatments: Focus on inflammatory bowel disease  Giammarco Mocci, Manuela Marzo, Alfredo Papa, Alessandro.
Anti-tumor necrosis factor-α induced systemic lupus erythematosus in a patient with metastatic Crohn's disease—what is the role of anti-TNF antibody? 

Anti-tumor necrosis factor-α induced systemic lupus erythematosus in a patient with metastatic Crohn's disease—what is the role of anti-TNF antibody? 
Collision adenocarcinoma–carcinoid tumor of the rectum arising in ulcerative colitis  Nobuyoshi Yamazaki, Yuji Nishizawa, Motohiro Kojima, Nobuhiro Sugano,

Collision adenocarcinoma–carcinoid tumor of the rectum arising in ulcerative colitis  Nobuyoshi Yamazaki, Yuji Nishizawa, Motohiro Kojima, Nobuhiro Sugano,
Concurrent small bowel adenocarcinoma and carcinoid tumor in Crohn's disease — Case report and literature review  Doron Boltin, Zohar Levi, Marisa Halpern,

Concurrent small bowel adenocarcinoma and carcinoid tumor in Crohn's disease — Case report and literature review  Doron Boltin, Zohar Levi, Marisa Halpern,
YouTube® and inflammatory bowel disease

YouTube® and inflammatory bowel disease
A case report: Ulcerative colitis, treatment with an antibody against tumor necrosis factor (infliximab), and subsequent liver necrosis  Urpo Kinnunen,

A case report: Ulcerative colitis, treatment with an antibody against tumor necrosis factor (infliximab), and subsequent liver necrosis  Urpo Kinnunen,
Incidence of ulcerative colitis and Crohn's disease in Danish children: Still rising or levelling out?  Christian Jakobsen, Vibeke Wewer, Frederikke Urne,

Incidence of ulcerative colitis and Crohn's disease in Danish children: Still rising or levelling out?  Christian Jakobsen, Vibeke Wewer, Frederikke Urne,
Liver abscess of the caudate lobe due to Staphylococcus aureus in an ulcerative colitis patient: First case report  Andreia Albuquerque, Fernando Magro,

Liver abscess of the caudate lobe due to Staphylococcus aureus in an ulcerative colitis patient: First case report  Andreia Albuquerque, Fernando Magro,
High and increasing prevalence of inflammatory bowel disease in Finland with a clear North–South difference  Airi Jussila, Lauri J. Virta, Veikko Salomaa,

High and increasing prevalence of inflammatory bowel disease in Finland with a clear North–South difference  Airi Jussila, Lauri J. Virta, Veikko Salomaa,
Prevalence of irritable bowel syndrome (IBS) in first-degree relatives of patients with inflammatory bowel disease (IBD)  Mariam Aguas, Vicente Garrigues,

Prevalence of irritable bowel syndrome (IBS) in first-degree relatives of patients with inflammatory bowel disease (IBD)  Mariam Aguas, Vicente Garrigues,
Microscopic colitis patients have increased proportions of Ki67+ proliferating and CD45RO+ active/memory CD8+ and CD4+8+ mucosal T cells  Ashok Kumar.

Microscopic colitis patients have increased proportions of Ki67+ proliferating and CD45RO+ active/memory CD8+ and CD4+8+ mucosal T cells  Ashok Kumar.

Similar presentations

Ads by Google