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Microscopic colitis patients have increased proportions of Ki67+ proliferating and CD45RO+ active/memory CD8+ and CD4+8+ mucosal T cells  Ashok Kumar.

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Presentation on theme: "Microscopic colitis patients have increased proportions of Ki67+ proliferating and CD45RO+ active/memory CD8+ and CD4+8+ mucosal T cells  Ashok Kumar."— Presentation transcript:

1 Microscopic colitis patients have increased proportions of Ki67+ proliferating and CD45RO+ active/memory CD8+ and CD4+8+ mucosal T cells  Ashok Kumar Kumawat, Hilja Strid, Kristina Elgbratt, Curt Tysk, Johan Bohr, Elisabeth Hultgren Hörnquist  Journal of Crohn's and Colitis  Volume 7, Issue 9, Pages (October 2013) DOI: /j.crohns Copyright © 2012 European Crohn's and Colitis Organisation Terms and Conditions

2 Figure 1 Proportions of intraepithelial CD8+ T cells (A) and activated/memory (CD45RO+) (B) and proliferating (Ki67+) (D) cells within this population in patients with collagenous colitis (CC), CC-histopathological remission (CC-HR), lymphocytic colitis (LC), LC-histopathological remission (LC-HR) and ulcerative colitis (UC), as well as correlation analysis (C) between the proportion of CD45RO+CD8+ T cells and age in controls (controls, n=9; CC, n=6; CC-HR, n=4; LC, n=6; LC-HR, n=5 and UC, n=3). Data are presented in box-plots; the horizontal line in the box represents the median. *, **=p<0.05, <0.01 vs controls, #=p<0.05 vs CC, $=p<0.05 vs UC. Journal of Crohn's and Colitis 2013 7, DOI: ( /j.crohns ) Copyright © 2012 European Crohn's and Colitis Organisation Terms and Conditions

3 Figure 2 Proportions of intraepithelial CD4+ T cells (A) and activated/memory (CD45RO+) (B) cells within this population in patients with collagenous colitis (CC), CC-histopathological remission (CC-HR), lymphocytic colitis (LC), LC-histopathological remission (LC-HR) and ulcerative colitis (UC), as well as correlation analysis (C) between the proportion of CD45RO+CD4+ T cells and age in controls (controls, n=9; CC, n=6; CC-HR, n=3; LC, n=6; LC-HR, n=4 and UC, n=3). Data are presented in box-plots; horizontal line in the box represents the median. *=p<0.05 vs controls, #, ##=p<0.05, <0.01 vs CC, £=p<0.05 vs LC. Journal of Crohn's and Colitis 2013 7, DOI: ( /j.crohns ) Copyright © 2012 European Crohn's and Colitis Organisation Terms and Conditions

4 Figure 3 Proportion of intraepithelial CD4+8+ T cells in patients with collagenous colitis (CC), CC-histopathological remission (CC-HR), lymphocytic colitis (LC), LC-histopathological remission (LC-HR), ulcerative colitis (UC) and controls (controls, n=6; CC, n=5; CC-HR, n=1; LC, n=6; LC-HR n=4 and UC, n=3). Data are presented in box-plots; horizontal line in the box represents the median. *=p<0.05 vs controls. Journal of Crohn's and Colitis 2013 7, DOI: ( /j.crohns ) Copyright © 2012 European Crohn's and Colitis Organisation Terms and Conditions

5 Figure 4 Proportions of lamina propria CD8+ T cells (A) and activated/memory (CD45RO+) (B) and proliferating (Ki67+) (D) cells within this population in patients with collagenous colitis (CC), CC-histopathological remission (CC-HR), lymphocytic colitis (LC), LC-histopathological remission (LC-HR) and ulcerative colitis (UC) as well as correlation analysis (C) between the proportion of CD45RO+CD8+T cells and age in controls (controls, n=9; CC, n=7; CC-HR, n=4; LC, n=6; LC-HR, n=6 and UC, n=4). Data are presented in box-plots; horizontal line in the box represents the median. *, **=p<0.05, <0.01 vs controls, #=p<0.05 vs CC, $=p<0.05 vs UC. Journal of Crohn's and Colitis 2013 7, DOI: ( /j.crohns ) Copyright © 2012 European Crohn's and Colitis Organisation Terms and Conditions

6 Figure 5 Proportions of lamina propria CD4+ T cells (A) and activated/memory (CD45RO+) (B) and proliferating (Ki67+) (D) cells within this population in patients with collagenous colitis (CC), CC-histopathological remission (CC-HR), lymphocytic colitis (LC), LC-histopathological remission (LC-HR) and ulcerative colitis (UC) as well as correlation analysis (C) between the proportion of CD45RO+CD4+T cells and age in controls (controls, n=9; CC, n=6; CC-HR, n=4; LC, n=6; LC-HR, n=5 and UC, n=4). Data are presented in box-plots; horizontal line in the box represents the median. *, **=p<0.05, <0.01 vs controls, ££=p<0.01 vs LC. Journal of Crohn's and Colitis 2013 7, DOI: ( /j.crohns ) Copyright © 2012 European Crohn's and Colitis Organisation Terms and Conditions

7 Figure 6 Proportion of lamina propria CD4+8+ T cells (A) and activated/memory (CD45RO+) cells (B) within this population in patients with collagenous colitis (CC), CC-histopathological remission (CC-HR), lymphocytic colitis (LC), LC-histopathological remission (LC-HR), ulcerative colitis (UC) and controls (controls, n=9; CC, n=5; CC-HR, n=4; LC, n=6; LC-HR, n=5 and UC, n=4). Data are presented in box-plots; horizontal line in the box represents the median. *=p<0.05 vs controls. Journal of Crohn's and Colitis 2013 7, DOI: ( /j.crohns ) Copyright © 2012 European Crohn's and Colitis Organisation Terms and Conditions

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