1. What does this protein make up or do? SA A
Chapter 1: Chromosome 1
DNA Sequence
Chromosome
81,519 bp
Name of Protein 1
Name of Gene
Ski uncogene
SKI
transcription
Amino acid sequence
mRNA
728 aa
translation
Cytoplasm
A Cell
Nucleus
What does this protein make up or do? SA A
The SKI gene provides instructions for making a protein involved in a signaling pathway that transmits chemical signals from the cell surface to the nucleus.
Condition/Disease
Breast Cancer

2. Description of Glaucoma
Symptoms and characteristics
A change in how the breast or nipple feels
A change in the breast or nipples appearance
Any nipple discharge- particularly clear discharge or bloody discharge.
Breast cancer is a malignant tumor that starts in the cells of the breast. A malignant tumor is a group of cancer cells that can grow into (invade) surrounding tissues or spread (metastasize) to distant areas of the body. The disease occurs almost entirely in women, but men can get it, too.

3. Description of Breast Cancer
Who is affected? Anyone, but the following have a higher risk:
Being female (Breast cancer can occur in men, but it is rare.)
Having a family history of breast cancer
Having your first child after age 35 or never having children
Reaching menopause after age 55
Getting your period early in life (before age 12)
Outlook or quality of life
Absence of symptoms (such as pain and fatigue)
Survival rates are higher in the early stages of breast cancer, early diagnosis and treatment is crucial
The hormone receptors on cells with cancer or the types of tissue that the cancer has affected
There are some cure to a few types of breast cancer
Researcher: DV

4. References
Heathline: Metastic Breast Cancer: Life expectancy and prognosis. Available at:
NCBI: SKI cogene. Available at:
Genetics Home Reference: Chromosome 1. Available at: Genes on Chromosome 1. Available at: SKI. Available at:
American Cancer Society: Breast Cancer. Available at: