1. Lymphatic System & Immune Response

2. LYMPHATIC SYSTEM
Network of tissues and organs that help rid the body of toxins & waste
Includes:
Lymphatic vessels
Lymph nodes
Lymphoid organs
Thymus
Tonsils
Spleen

3. Cardiovascular / Lymphatic Loop
Osmotic pressure pushes liquid out of the capillaries
Extracellular fluid is renewed and cells are bathed in nutrients/hormones/gases
Pressure returns fluid back into capillaries --- some goes into lymphatic vessels
Fluid is called lymph and travels to lymph nodes where macrophages remove abnormal cells and microbes
Lymph ducts join with veins and return lymph back to blood

5. Lymphatic Vessels Occur adjacent to vascular system vessels
Contain valves to prevent back-flow
Larger lymphatics empty into veins
Thoracic duct – most of the lymph is returned to circulation
Cisterna Chyli – saclike portion of thoracic duct that delivers lymph from lower limbs, pelvis, and abdomen
Right lymphatic duct – returns lymph from upper right limbs, neck and chest

6. Lymph Nodes
Contain phagocytes and macrophages to remove bacteria, debris, and other antigens in the lymph
Scattered throughout the lymphatic system
What does a swollen lymph node indicate?

7. Implications in Breast Cancer

8. Lymphocytes leave the blood and enter node
Lymphocytes are produced
B cells and plasma cells
Rich in B cells

9. Lymphatic Nodules
Found in connective tissue under lining of digestive, urinary and respiratory systems
The lymph in nodules encounters macrophages/lymphocytes and microbes in the lymphs are removed
Ex. Tonsils, Peyers Patches

10. The Spleen Largest lymphatic organ in the body Red pulp White pulp
Phagocytes remove abnormal RBC’s and antigens
Lymphocytes start producing antibodies
Contain trabecular arteries
White pulp
Contain central arteries

11. Immune Response Innate vs Adaptive Memory, Specificity, Self-Tolerance
B cells vs T cells
T cells
Helper cells
Cytotoxic cells
B cells
Memory vs Plasma cells
Form antibodies (immunoglobulins)

12. Clonal Selection

13. Antibodies for Cancer?