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The Lymphatic System and Immune Response

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Presentation on theme: "The Lymphatic System and Immune Response"— Presentation transcript:

1 The Lymphatic System and Immune Response
Exercise 38 The Lymphatic System and Immune Response

2 Lymphatic System Lymphatic vessels Lymphatic tissues Tonsils
Primary lymphatic organs Thymus and Bone marrow Secondary lymphatic organs Lymph nodes, spleen

3 Lymphatic System

4 Lymphatic System Lymph Fluid lost from the capillaries Edema
Functions of the lymphatic system: Transport lymph to the blood vessels Protects the body

5 Lymphatic vessels Lymphatic capillaries Lymphatic collecting vessels
Lymphatic trunk Right lymphatic duct - drains lymph from: Head right upper extremity Right thorax Drains into right subclavian vein

6 Lymphatic vessels Thoracic duct – drains lymph from: Rest of the body
Drains into left subclavian vein Cisterna chyli Characteristic of the lymphatic vessels Walls with 3 tunics Presence of valves Presence of abundant anastomoses

7 Lymphatic vessels

8 Primary lymphoid organs
Bone marrow Contain the stem cell that will give rise to all lymphocytes Site of B cell differentiation or immunocompetency Thymus Site of T cell differentiation or immunocompetency

9 Thymus

10 Secondary lymphatic organs
Lymph nodes Bean-shaped Numerous Regional lymph nodes: Cervical Axillary Inguinal, etc Hilus Afferent and efferent vessels

11 Secondary lymphatic organs
Microscopy Capsule and subcapsular sinus Trabecula Cortex Outer cortex (follicles) Germinal center containing dividing B cells Deep cortex or paracortical area Contain T cells

12 Secondary lymphatic organs
Medulla Medullary cords Medullary sinuses Contain macrophages and plasma cells

13 Secondary lymphatic organs
Spleen Capsule White pulp Central artery Lymphocytes Red pulp Venous sinuses Reticular tissue Macrophages arranged I splenic cords

14 Spleen

15 Lymphoid tissues Tonsils One pharingeal Two palatines Two linguals
Presence of germinal center Presence of crypts

16 Tonsils

17 The immune response It is a systemic response
Destroys or neutralizes foreign substances Characteristics of immune responses Memory Immunocompetent lymphocytes are monospecific Specificity Ability to differentiate self from nonself

18 The immune response Antigens Foreign proteins Polysaccharides Haptens
Lymphocytes Responsible for the immune response Autoimmunity

19 Organ, cells and cell interaction of the immune response
Hemocytoblasts in the bone marrow give rise to lymphocytes Types of Lymphocytes: B - will stay in the bone marrow for maturation (immunocompetence) T - will migrate to thymus for maturation (immunocompetence) Natural Killers

20 Organ, cells and cell interaction of the immune response
B and T cell will then leave bone marrow and thymus, enter the blood stream and travel to secondary lymphatic organs Site for clonal selection

21 Organ, cells and cell interaction of the immune response
B and T cell will bind to specific antigens and then undergo clonal multiplication B cell may become Memory Plasma cell Humoral immunity

22 Organ, cells and cell interaction of the immune response
T cell may become Memory Cytotoxic Helper Suppressor Cellular immunity

23 Antibodies and tests for their presence
Characteristics of antibodies or Immunoglobulins (Igs) Produced only by plasma cells They are plasma proteins (gamaglobulins) Found in all body secretions

24 Antibodies and tests for their presence
Classes of antibodies IgM, IgG, IgA, IgD, IgE Structure of the immunoglobulins 2 heavy chains 2 light chains

25 Antibody

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