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A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature  Matthias Manne Knopp, Natasha Gannon, Ilona Porsch, Malte Bille Rask, Niels.

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Presentation on theme: "A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature  Matthias Manne Knopp, Natasha Gannon, Ilona Porsch, Malte Bille Rask, Niels."— Presentation transcript:

1 A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature 
Matthias Manne Knopp, Natasha Gannon, Ilona Porsch, Malte Bille Rask, Niels Erik Olesen, Peter Langguth, René Holm, Thomas Rades  Journal of Pharmaceutical Sciences  Volume 105, Issue 9, Pages (September 2016) DOI: /j.xphs Copyright © 2016 American Pharmacists Association® Terms and Conditions

2 Figure 1 Illustration of the basic principle behind the new polymer in solution method. The increase in CCX solubility is plotted as a function of PVP concentration in methanol (■) and ethanol (▴) at 25°C. The solid line is the best linear fit, and the dotted lines are the (nonlinear) prediction intervals. Data points represent raw data (n = 2). Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2016 American Pharmacists Association® Terms and Conditions

3 Figure 2 Comparison of the solubility predictions for all investigated drug-polymer systems obtained from the melting point depression method (●) with the solubility estimates obtained from the new polymer in solution method using methanol (■) and ethanol (▴) as solvents. Data points represent mean drug-polymer solubility (w/w) at 25°C including the prediction intervals. Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2016 American Pharmacists Association® Terms and Conditions

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