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Paclitaxel-Loaded Magnetic Nanoparticles: Synthesis, Characterization, and Application in Targeting  Jilai Tian, Caiyun Yan, Kunliang Liu, Juan Tao, Zhenchao.

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Presentation on theme: "Paclitaxel-Loaded Magnetic Nanoparticles: Synthesis, Characterization, and Application in Targeting  Jilai Tian, Caiyun Yan, Kunliang Liu, Juan Tao, Zhenchao."— Presentation transcript:

1 Paclitaxel-Loaded Magnetic Nanoparticles: Synthesis, Characterization, and Application in Targeting 
Jilai Tian, Caiyun Yan, Kunliang Liu, Juan Tao, Zhenchao Guo, Jianping Liu, Yu Zhang, Fei Xiong, Ning Gu  Journal of Pharmaceutical Sciences  Volume 106, Issue 8, Pages (August 2017) DOI: /j.xphs Copyright © 2017 American Pharmacists Association® Terms and Conditions

2 Figure 1 Schematic of PTX-loaded modified by PLO and its kidney targeting application. Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

3 Figure 2 Effect of different molecular weight of PLO on PTX-MNPs, among which, ①, ②, and ③ represented the PTX-MNPs-PLO1000, PTX-MNPs-PLO2000, PTX-MNPs-PLO4000, respectively. (a) EE% of PTX, (b) loaded content rate of Fe, (c) the particle size (column) and PDI (line). (Particle size: PTX-MNPs-PLO1000 vs. PTX-MNPs-PLO4000, p < 0.05, PTX-MNPs-PLO2000 vs. PTX-MNPs-PLO4000, p < 0.05). Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

4 Figure 3 (a) Hysteresis loops for PTX-MNPs-PLO1000, PTX-MNPs-PLO2000, and PTX-MNPs-PLO4000; MRI properties of PTX-MNPs-PLO2000. (b) Signal intensity–weighted images (TR = 2500 ms; TE = 10 ms) of MNPs in 1% agarose solution at various iron concentrations at room temperature. Blank agarose solution was taken as a control. (c) Changes of T2 relaxation rate (R2) of MNPs as iron concentration increased. Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

5 Figure 4 (a and b) Transmission electron microscopy images of and PTX-MNPs-PLO2000, respectively, whereas (c and d) represented SEM images of PTX-MNPs-PLO2000 and in sequence. (e) The TGA of and PTX-MNPs-PLO2000. (f) The VSM of and PTX-MNPs-PLO2000. Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

6 Figure 5 Results of (a) XRD and (b) FT-IR.
Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

7 Figure 6 Plasma concentration-time profiles in rats after intravenous administration (n = 3). Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

8 Figure 7 (a) The concentration-time curves of PTX in tissues of mice given PTX-MNPs-PLO2000 after intravenous administration in different magnetic fields. (b) Comparison of AUC of PTX tissues of mice given PTX-MNPs-PLO2000 after intravenous administration in different magnetic fields. All the magnetic intensities were assigned at 0, 0.6, and 1.2 T. No significant difference between left and right kidneys under both 0.6 and 1.2 T (p > 0.05). Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

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