1. TNT: Baseline and final LDL cholesterol levels
Atorvastatin 10 mg (n=5006)
Atorvastatin 80 mg (n=4995)
Mean baseline LDL cholesterol levels (mg/dL) 98 97
Final LDL cholesterol levels (mg/dL)
101 77
LaRosa JC et al. N Engl J Med 2005; available at:

2. TNT: Primary efficacy outcomes
Atorvastatin 10 mg (n=5006)
Atorvastatin 80 mg (n=4995)
Hazard ratio
(95% CI) p
Total major cardiovascular events (%)
10.9
8.7
0.78
( )
<0.001
Death from coronary heart disease (%)
2.5
2.0
0.80
( )
0.09
Nonfatal MI (%)
6.2
4.9
( )
0.004
Resuscitation after cardiac arrest (%)
0.5
0.96
( )
0.89
Fatal or nonfatal stroke (%)
3.1
2.3
0.75
( )
0.02
LaRosa JC et al. N Engl J Med 2005; available at: