Presentation is loading. Please wait.

Presentation is loading. Please wait.

Evaluation of New Chemical Entities as Substrates of Liver Transporters in the Pharmaceutical Industry: Response to Regulatory Requirements and Future.

Published byMaría Pilar Quintero Naranjo Modified over 5 years ago

Similar presentations

Presentation on theme: "Evaluation of New Chemical Entities as Substrates of Liver Transporters in the Pharmaceutical Industry: Response to Regulatory Requirements and Future."— Presentation transcript:

1 Evaluation of New Chemical Entities as Substrates of Liver Transporters in the Pharmaceutical Industry: Response to Regulatory Requirements and Future Steps  Noriko Okudaira  Journal of Pharmaceutical Sciences  Volume 106, Issue 9, Pages (September 2017) DOI: /j.xphs Copyright © 2017 American Pharmacists Association® Terms and Conditions

2 Figure 1 Studies conducted for hepatic transporter substrates during drug discovery and development. Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

3 Figure 2 Total body clearance of bromosulphophthalein (BSP) and statins in rats after a single intravenous administration with and without oral rifampicin (30 mg/kg). Dose of BSP and statins were 3 mg/kg and 1 mg/kg, respectively. Closed bar and open bar represent total body clearance (CLtot) without and with rifampicin, respectively. Data are expressed as mean ± SE (n = 3). **p < 0.01, *p < 0.05. Data were obtained from the study by Imaoka et al.15 Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

4 Figure 3 The hepatic Kp ratios for OATP substrates and non-OATP substrates. Hepatic Kp ratio: The ratio of hepatic Kp to the mean Kp values of adrenal gland, fat, heart, kidney, lung, pancreas, skeletal muscle, skin spleen, and thymus. Data were obtained from the study by Mikkaichi et al.19 Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

5 Figure 4 Media-loss assay and metabolic stability assay for atorvastatin and midazolam in freshly isolated female SD rat hepatocytes. The percentages of each residual compound found at 0.25 min in the media-loss assay with or without 100 μM of rifampicin and at 0 min in the metabolic stability assay are plotted. Average of duplicate assays. Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

Download ppt "Evaluation of New Chemical Entities as Substrates of Liver Transporters in the Pharmaceutical Industry: Response to Regulatory Requirements and Future."

Similar presentations

Connexin Mutations in Skin Disease and Hearing Loss David P. Kelsell, Wei-Li Di, Mark J. Houseman The American Journal of Human Genetics Volume 68, Issue.

Connexin Mutations in Skin Disease and Hearing Loss David P. Kelsell, Wei-Li Di, Mark J. Houseman The American Journal of Human Genetics Volume 68, Issue.
Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.
Effects of Milk Powders in Milk Chocolate B. Liang, R.W. Hartel Journal of Dairy Science Volume 87, Issue 1, Pages 20-31 (January 2004) DOI: 10.3168/jds.S0022-0302(04)73137-9.

Effects of Milk Powders in Milk Chocolate B. Liang, R.W. Hartel Journal of Dairy Science Volume 87, Issue 1, Pages (January 2004) DOI: /jds.S (04)
Clearance Prediction of HIV Protease Inhibitors in Man: Role of Hepatic Uptake Tom De Bruyn, Bruno Stieger, Patrick F. Augustijns, Pieter P. Annaert Journal.

Clearance Prediction of HIV Protease Inhibitors in Man: Role of Hepatic Uptake Tom De Bruyn, Bruno Stieger, Patrick F. Augustijns, Pieter P. Annaert Journal.
2002 Air Medical Transport Industry Awards Air Medical Journal Volume 22, Issue 2, Pages 16-18 (March 2003) DOI: 10.1016/S1067-991X(03)70032-7 Copyright.

2002 Air Medical Transport Industry Awards Air Medical Journal Volume 22, Issue 2, Pages (March 2003) DOI: /S X(03) Copyright.
Characterization of bovine glucose transporter 1 kinetics and substrate specificities in Xenopus oocytes P.A. Bentley, Y. Shao, Y. Misra, A.D. Morielli,

Characterization of bovine glucose transporter 1 kinetics and substrate specificities in Xenopus oocytes P.A. Bentley, Y. Shao, Y. Misra, A.D. Morielli,
Oral administration of bovine lactoferrin attenuates ultraviolet B-induced skin photodamage in hairless mice M. Murata, T. Satoh, H. Wakabayashi, K. Yamauchi,

Oral administration of bovine lactoferrin attenuates ultraviolet B-induced skin photodamage in hairless mice M. Murata, T. Satoh, H. Wakabayashi, K. Yamauchi,
Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism ‐ Based Prediction of Volume of Distribution Patrick Poulin, Frank ‐ Peter Theil.

Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism ‐ Based Prediction of Volume of Distribution Patrick Poulin, Frank ‐ Peter Theil.
Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4- aminoquinoline anti-malarials  Charles B. Davis, Ramesh Bambal, Ganesh.

Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4- aminoquinoline anti-malarials  Charles B. Davis, Ramesh Bambal, Ganesh.
Xiaodong Zhou, Anne M. Smith, Mark L. Failla, Kristina E

Xiaodong Zhou, Anne M. Smith, Mark L. Failla, Kristina E
Gautam A. Madan, MDS, Sonal G. Madan, MDS, Gauri Madan, MDS, A. D

Gautam A. Madan, MDS, Sonal G. Madan, MDS, Gauri Madan, MDS, A. D
Paclitaxel-Loaded Magnetic Nanoparticles: Synthesis, Characterization, and Application in Targeting  Jilai Tian, Caiyun Yan, Kunliang Liu, Juan Tao, Zhenchao.

Paclitaxel-Loaded Magnetic Nanoparticles: Synthesis, Characterization, and Application in Targeting  Jilai Tian, Caiyun Yan, Kunliang Liu, Juan Tao, Zhenchao.
Photochemical Mechanism of Riboflavin-Induced Degradation of Famotidine and a Suggested Pharmaceutical Strategy for Improving Photostability  Atsushi.

Photochemical Mechanism of Riboflavin-Induced Degradation of Famotidine and a Suggested Pharmaceutical Strategy for Improving Photostability  Atsushi.
Investigation of the effect of active efflux at the blood–brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous.

Investigation of the effect of active efflux at the blood–brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous.
Pulmonary Delivery of the Kv1

Pulmonary Delivery of the Kv1
Synthesis and in vitro characterization of drug conjugates of l-carnitine as potential prodrugs that target human Octn2  Lei Diao, James E. Polli  Journal.

Synthesis and in vitro characterization of drug conjugates of l-carnitine as potential prodrugs that target human Octn2  Lei Diao, James E. Polli  Journal.
A Practical Framework Toward Prediction of Breaking Force and Disintegration of Tablet Formulations Using Machine Learning Tools  Ilgaz Akseli, Jingjin.

A Practical Framework Toward Prediction of Breaking Force and Disintegration of Tablet Formulations Using Machine Learning Tools  Ilgaz Akseli, Jingjin.
A clinician's guide to statin drug-drug interactions

A clinician's guide to statin drug-drug interactions
The Disposition of Oxymatrine in the Vascularly Perfused Rat Intestine-Liver Preparation and Its Metabolism in Rat Liver Microsomes  Li Hua Huang, Yun Ming.

The Disposition of Oxymatrine in the Vascularly Perfused Rat Intestine-Liver Preparation and Its Metabolism in Rat Liver Microsomes  Li Hua Huang, Yun Ming.
Formulation of 3D Printed Tablet for Rapid Drug Release by Fused Deposition Modeling: Screening Polymers for Drug Release, Drug-Polymer Miscibility and.

Formulation of 3D Printed Tablet for Rapid Drug Release by Fused Deposition Modeling: Screening Polymers for Drug Release, Drug-Polymer Miscibility and.

Similar presentations

Ads by Google