1. Suppl 4A Large black circles: query genes
Grey circles: interacting or related proteins
Purple: Co expression
Light blue: Colocalization
Light green: genetic interactions
Functions
1. Negative regulation of motility
2. Androgen metabolism
3. Hydrolase activity

2. Suppl 4B Functions 1. Small molecule biosynthesis
2. Steroid metabolism
3. Alcohol metabolism
4. Cholesterol metabolism
5. Sterol metabolism
6. Organic hydroxy compounds, carboxylic acid, organic acid and fatty acid metabolism (including fatty acid beta oxidation)

3. Suppl 4C Light grey: consolidated pathways Red: Physical interactions
Blue: Pathway
Functions
1. GPI anchor bioassembly in ER membrane
2. C-terminal amino acid modification
3. Protein lipidation
4. Glycolipid, lipoprotein, phosphatidylinositol biosynthesis
5. Glycerophospholipid metabolism
6. Fibroblast growth factor and insulin receptor receptor signaling pathway
7. Transferase, mannosyltransferase, phosphotransferase activity
8. Positive regulator of ERK1/ERK2 cascade

4. Suppl 4D Purple: Co-expression Functions
1. SRP dependent cotranslational protein targeting to membrane
2. Cytosolic ribosome
3. Translation elongation and termination
4. Protein localization to ER
5. Nonsense mediated decay of mRNA
6. Viral genome expression, reproduction

5. Suppl 4E Light blue: Pathways Yellow: Predicted interaction
Light grey: consolidated pathways
Functions
1. Cellular response to metal ions (zinc, cadmium, inorganic metals, transition metals)
2. Negative regulation of growth
3. Primary alcohol metabolic process
4. Oxidoreductase activity

6. Suppl 4F
Light grey: transcription factor targets