1. Table S1: mRNAs Upregulated during TRAIL induced apoptosis
Gene
Function
Role
DNA Damage
PRKDC DNA-PK catalytic subunit DNA Damage Signalling
GADD45A CDK Binding DNA Damage Response
CIB1 Unknown DNA end joining
MSH2 DNA Mismatch Recognition Mismatch Repair
XRCC5 DNA Helicase Non-homologous end joining
Metabolism
NDUFV2 Oxidoreductase Electron Transport
TYMS dTMP synthetase Nucleotide Metabolism
GOT2 Transaminase Amino Acid Metabolism
GSTM3 Glutathione S-transferase Xenobiotic Metabolism
GLB1 Galactosidase Ganglioside Metabolism
NDUFS1 Oxidoreductase Electron Transport
MAT2A AdoMet Synthesis Methionine Metabolism
GLO1 Glyoxalase Glutathionine Metabolism
GPX4 Peroxidase Hydrogen Peroxide Protection
ALDOC Fructose Aldolase Carbohydrate Metabolism
BLVRA Biliverdin Reductase Redox Cycle
ACADS Acyl-coenzyme A dehydrogenase Fatty Acid Metabolism
GSTZ1 Glutathione S-transferase Amino Acid Catabolism
ALDOC Aldolase Glycolysis
Apoptosis
SIAH2 E3 Ligase Apoptosis
BCL2L1 Bcl-2 family member Anti-Apoptotic
DNASE1L3 DNAse DNA Cleavage
CASP4 Caspase Pro-Apoptotic
SIVA TNFR family member Pro-Apoptotic
Cell Signalling
CREM Transcription Factor cAMP Signalling
RREB1 Transcription Factor MAPK Signalling
MAPK1 Mitogen Signalling MAPK Signalling
GRB10 Mitogen Signalling Growth Factor Signalling
MAP2K1 Mitogen Signalling MAPK Signalling
RAB3A Ras Associated Signalling
CTNND2 Cadherin Signalling Signalling
PIK3CB inositide kinase Mitogen Signalling
RANBP1 RAN Binding Signalling
GNB1 G-Protein Signalling
IFNAR2 Inteferon Receptor JAK/STAT Signalling
NOTCH4 Notch Signalling Signalling
Sub-Polysome
Polysome
Table S1: mRNAs Upregulated during TRAIL induced apoptosis