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Cell Communication III. G-protein linked receptor.

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Presentation on theme: "Cell Communication III. G-protein linked receptor."— Presentation transcript:

1 Cell Communication III

2 G-protein linked receptor

3 The structure of an inactive G-protein

4 Without signaling molecule G-protein is inactive

5 G-protein binds to receptor when signaling molecule is present

6 G-protein accepts GTP and disassemble into two active subunits

7 The α subunit of the G-protein can be deactivated through hydrolysis of GTP

8 Deactivation of G-protein

9 Reassembly of α subunit with other 2 subunits reforms inactive G-protein complex

10 Arrestin binds phosphorylated G-protein receptor and deactivates the receptor and prepares it for endocytosis

11 Activation of gene transcription by cAMP

12 Synthesis and degradation of cyclic AMP

13

14 Activation of cAMP dependent protein kinase

15 Activation of gene transcription by cAMP

16 Ca 2+ and diacylglycerol activate protein kinase C

17 Fertilization of an egg by a sperm triggers an increase in cytosolic Ca 2+

18 Ways in which a cell maintains a low Ca 2+ concentration in the cytosol

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20 When receptor chains crosslink the receptor is phosphorylated and activated

21 Human growth hormone bound to its receptor tyrosine kinase

22 Activated receptor kinase binds intracellular signaling proteins

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24 Ras is activated by tyrosine kinase

25 The Jak-STAT signaling pathway provides a fast track to the nucleus

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