1. W. Scott Campbell, MBA, PhD University of Nebraska Medical Center
Histopathology and Proposed Observable entity and evaluation procedure Model
W. Scott Campbell, MBA, PhD
University of Nebraska Medical Center

2. Surgical Pathology Overview
University of Nebraska Medical Center
Surgical Pathology Overview
Case
Clinical Findings
(Diagnoses)
Clinical Findings
Specimen
1..n 1
Clinical Findings
Blocks
Clinical Findings
Observations
1..n 1
Pathologist Examines Slides by Microscope with various stains
Observations lead to Clinical Findings Other patient information
Diagnoses rendered
Slides
1..n 1

3. Typical Pathology Report
University of Nebraska Medical Center
Typical Pathology Report
Final Diagnosis: RIGHT BREAST, VACUUM-ASSISTED NEEDLE CORE BIOPSY: - DUCTAL CARCINOMA IN SITU WITH EXTENSIVE PERIDUCTAL SCLEROSIS AND INFLAMMATION. - FOCUS SUSPICIOUS BUT NOT DIAGNOSTIC FOR MICROINVASION. - GROWTH PATTERN: SOLID. - NUCLEAR GRADE: HIGH. - NECROSIS: PRESENT. - MICROCALCIFICATION IN DCIS: YES. Microscopic Report: Performed
Finding and observation
Observations

4. Review of Common Histopathology Observations and Findings
University of Nebraska Medical Center
Review of Common Histopathology Observations and Findings
Observation of morphology (Model helpful)
Size of tumor (Model very helpful)
Histologic grades?
Possibility/Suspicion?
Finding vs. Observation
Situations…again!?!

5. Observation of morphology: Epithelial hyperplasia in breast biopsy
University of Nebraska Medical Center
Observation of morphology: Epithelial hyperplasia in breast biopsy
|IS ABOUT| (Property type?) = |Clinical finding|: { |Finding site|= |structure of small lactiferous ducts|, |Associated morphology|= |epithelial hyperplasia|}, |Scale| = |qualitative|, |Has value| = |present|, |Technique| = |Finding method|= ( |hematoxylin and eosin stain method| |histopathology test| |light microscopy|), |DIRECT SITE|= | specimen from breast obtained by image guided core biopsy|
Ability to call out staining methods important

6. Observation: Measurement of tumor extent
University of Nebraska Medical Center
Observation: Measurement of tumor extent
|IS ABOUT| = |PROPERTY TYPE| = |largest dimension of in situ neoplasm|, |INHERES IN| = |intraductal carcinoma, noninfiltrating|, |Scale| = |quantitative|, |Has value| = 1.7, |Units| = |mm|, |Technique| = |Finding method|= ( |hematoxylin and eosin stain method| |histopathology test| |light microscopy|), |DIRECT SITE|= | specimen from breast obtained by image guided core biopsy|

7. Histologic Grade (Option 1)
University of Nebraska Medical Center
Histologic Grade (Option 1)
|IS ABOUT| = |Clinical finding|: { |Finding site|= | lactiferous duct structure|, |Associated morphology|= |intraductal carcinoma, noninfiltrating, no ICD-O subtype|, |Associated with|= |nuclear pleomorphism, grade 2: neither nuclear grade 1 nor nuclear grade 3|}, |Scale| = |qualitative|, |Has value| = |present|, |Technique| = |Finding method|= ( |hematoxylin and eosin stain method| |histopathology test| |light microscopy|) , |DIRECT SITE|= | specimen from breast obtained by image guided core biopsy|

8. Histologic Grade (Option 2)
University of Nebraska Medical Center
Histologic Grade (Option 2)
|IS ABOUT| = |Clinical finding| = |nuclear pleomorphism, grade 2: neither nuclear grade 1 nor nuclear grade 3|, |INHERES IN| = |intraductal carcinoma, noninfiltrating|, |Scale| = |qualitative|, |Has value| = |present|, |Technique| = |Finding method|= ( |hematoxylin and eosin stain method| |histopathology test| |light microscopy|) |DIRECT SITE|= | specimen from breast obtained by image guided core biopsy|

9. Suspicion as an Observation
University of Nebraska Medical Center
Suspicion as an Observation
|IS ABOUT| = |Clinical finding|: { |Finding site|= | lactiferous duct structure|, |Associated morphology|= |infiltrating duct carcinoma|}, |Scale| = |qualitative|, |Has value| = |undetermined|, |Technique| = |Finding method|= ( |hematoxylin and eosin stain method| |histopathology test| |light microscopy|) |DIRECT SITE|= | specimen from breast obtained by image guided core biopsy|
|equivocal| ?

10. University of Nebraska Medical Center
Diagnostic Level Statement: Example: Ductal Carcinoma in situ suspicious for microinvasion
|situation with explicit context|: { |finding context| = |suspected|, |temporal context value| = |current – unspecified|, |subject relationship context| = |subject of record, |associated finding|= |clinical finding|: { |finding site| = |lactiferous duct structure|, |associated morphology| = |infiltrating duct carcinoma|} }

11. University of Nebraska Medical Center
Conclusions
Clarification of acceptable attribute/value domains and ranges
Continue to struggle with descriptive language for architectural features (pre-diagnostic or importance to be determined)
Suspicion and probability of the Clinical Finding (diagnostic lines)
Binding to synoptic reports

12. University of Nebraska Medical Center
Thank you

13. University of Nebraska Medical Center