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High-pressure liquid chromatography of deproteinized cerebrospinal fluid (CSF), plasma, and urine of an ADSL-deficient patient (left panels) and of a control.

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Presentation on theme: "High-pressure liquid chromatography of deproteinized cerebrospinal fluid (CSF), plasma, and urine of an ADSL-deficient patient (left panels) and of a control."— Presentation transcript:

1 High-pressure liquid chromatography of deproteinized cerebrospinal fluid (CSF), plasma, and urine of an ADSL-deficient patient (left panels) and of a control child (right panels). Samples equivalent to 50 μl were injected into an anion exchange column. The first of the twin peaks in the patient sample is S-Ado; the second is SAICAriboside. Dotted line shows percentage of high concentration eluate (B) in gradient. 254 nm: absorbance at 254 nm. (From Jaeken & Van den Berghe.1 Used by permission of The Lancet Ltd.) Source: Adenylosuccinate Lyase Deficiency, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: November 22, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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