1. SWAG SSG Sarcoma Meeting
Clinical Research Network
West of England
SWAG SSG Sarcoma Meeting
Tuesday 31st January 2017

2. Clinical Research Network & Cancer Services
West ofEngland
SWAG - Somerset Wiltsire Avon & Gloucestershire
South West Children’s Cancer & Leukaemia
Research Network

3. NIHR CRN High Level Objectives
Increase number of participants into NIHR CRN portfolio studies
650,000 in England
21,905 in West of England
Increase the number of studies that deliver to time and target
Target 80%
Increase number of commercial studies delivered through network
Reduce NHS study set up times
Reduce time taken to recruit first participant

4. NIHR CRN Objectives for cancer
Recruit 20% of cancer incidence
West of England 1,909
Recruit 7.5% of cancer incidence into interventional studies
716
Include challenging studies
Cancer surgery – 4 recruits per 100,000 population
Radiotherapy – 6 recruits per 100,000 population
Rare cancers (<6 per 100,000) – 12 recruits per 100,000 population
Children & young people – 3 per 100,000 population
Teenagers & young adults – record number of year olds participating in research

7. Due to the complexity in classifying Sarcoma within the ICD-10 it was not possible to calculate recruitment as a % of Sarcoma incidence by LCRN. However according to Cancer Research UK (2014) figures for England as a whole, 5.8% of annual new registrations of Sarcoma were recruited into trials between April and December 2016.

8. Open studies in SWAG – Sarcoma
NIHR ID
Project Title
Trust
Principal Investigator
BRAG
Planned end date
Recruited
Target
19629
IMRiS: Phase II study of IMRT in primary bone and soft tissue sarcoma
Gloucestershire Hospitals
Candish, Dr Charlie
-31.13%
04/03/2018 1 10
11721
STRASS: A phase III randomized study of preoperative radiotherapy plus surgery versus surgery alone for patients with Retroperitoneal sarcoma (RPS)
University Hospitals Bristol
Ayre, Dr Gareth
-50.92%
09/01/2017 2 4
13804
Euro Ewing 2012
Rees, Dr Helen
50.96%
01/09/2024 3
17239
rEECur
-14.71%
01/01/2020 8
BRAG
Open studies
Black
Study not reported recruitment or study has not recruited
Red
% Recruitment is more than 30 behind % time elapsed, i.e. Difference < -30
Amber
% Recruitment is less than 30 behind % elapsed time but more than 0 behind % elapsed time, i.e. -30 < Difference < 0
Green
% Recruitment is equal to or greater than % elapsed time, i.e. Difference >= 0
Grey
Unable to calculate RAG due to record missing at least one data point

9. Studies in set up – Sarcoma
NIHR Study ID
Title
Trust
Principal Investigator
19110
CANC A Phase 1/2 Study of FPA008 in patient with PVNS or dt-TGCT
University Hospitals Bristol
19629
IMRiS: Phase II study of IMRT in primary bone and soft tissue sarcoma
Ayre, Dr Gareth
30650
IDRIS

10. Useful links https://www.crn.nihr.ac.uk/
National and local network information including training programmes templates, tools, contacts, videos etc
Open data platform. Look at performance across whole CRN including all specialty areas
/csg.ncri.org.uk/portfolio/portfolio-maps/
View current national portfolio of open, closed and ‘in set up’ cancer studies
See where a study is open across the country
Search for a study to fit criteria. Good for horizon scanning, eligibility criteria

11. Contacts Research Delivery Manager – maxine.taylor@nihr.ac.uk
Cancer portfolio facilitator –
Clinical Lead –