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Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure  Philipp Badorrek, MD,

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Presentation on theme: "Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure  Philipp Badorrek, MD,"— Presentation transcript:

1 Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure  Philipp Badorrek, MD, Meike Müller, PhD, Wolfgang Koch, PhD, Jens M. Hohlfeld, MD, Norbert Krug, MD  Annals of Allergy, Asthma & Immunology  Volume 118, Issue 3, Pages (March 2017) DOI: /j.anai Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

2 Figure 1 Mean total nasal symptom score (TNSS) of the last 5 measurements during challenge in healthy participants and patients with allergic rhinitis on challenge day 1 (left) and challenge day 2 (right). The data are displayed in a box-and-whiskers graph. The box extends from the 25th percentile to the 75th percentile, with a line at the median. The whiskers extend to the highest and lowest value. Asterisk indicates a significant (P < .001) difference between healthy participants and patients with allergic rhinitis. Annals of Allergy, Asthma & Immunology  , DOI: ( /j.anai ) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

3 Figure 2 Nasal flow measured by rhinomanometry in healthy participants (left) and patients with allergic rhinitis (right) for challenge day 1 (top) and challenge day 2 (bottom). The data are displayed in a box-and-whiskers graph (see legend for Fig 1). Asterisk indicates a significant decrease (P < .05) compared with baseline (before). Annals of Allergy, Asthma & Immunology  , DOI: ( /j.anai ) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

4 Figure 3 Relative percentage of eosinophils in healthy participants (left) and patients with allergic rhinitis (right) for challenge day 1 (top) and challenge day 2 (bottom). The data are displayed in a box-and-whiskers graph (see legend for Fig 1). Asterisk indicates a significant increase (P < .05) compared with baseline (before). Reproduced with permission from Krug et al12 (copyright 2012 Wiley). Annals of Allergy, Asthma & Immunology  , DOI: ( /j.anai ) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

5 Figure 4 Interleukin (IL) 5 (A), IL-6 (B), and macrophage inflammatory protein (MIP) 1β (C) levels in healthy participants (left) and patients with allergic rhinitis (right) for challenge day 1 (top) and day 2 (bottom). Cytokines were measured in nasal secretion of patients with allergic rhinitis and healthy participants at the times shown in the graphs. The data are displayed in a box-and-whiskers graph (see legend for Fig 1). Asterisk indicates a significant (P < .05) increase and dagger indicates a significant (P < .05) decrease compared with baseline (before). Annals of Allergy, Asthma & Immunology  , DOI: ( /j.anai ) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

6 Figure 5 Interleukin (IL) 13 (A) and eotaxin (B) were measured in nasal secretion–soaked filter papers of patients with allergic rhinitis and healthy participants at the times shown in the graphs. The data are displayed in a box-and-whiskers graph (see legend for Fig 1). Asterisk indicates a significant (P < .05) increase in patients with allergic rhinitis. Annals of Allergy, Asthma & Immunology  , DOI: ( /j.anai ) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

7 Figure 6 Nasal nitric oxide measurements in healthy participants (left) and patients with allergic rhinitis (right) for challenge day 1 (top) and challenge day 2 (bottom). The data are displayed in a box-and-whiskers graph (see legend for Fig 1). Asterisk indicates a significant increase (P < .05) and dagger indicates a significant decrease (P < .05) compared with baseline (before). Annals of Allergy, Asthma & Immunology  , DOI: ( /j.anai ) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

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