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Efficacy and safety of birch pollen immunotherapy for local allergic rhinitis  Andrzej Bożek, MD, PhD, Krzysztof Kołodziejczyk, MD, PhD, Jerzy Jarząb,

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Presentation on theme: "Efficacy and safety of birch pollen immunotherapy for local allergic rhinitis  Andrzej Bożek, MD, PhD, Krzysztof Kołodziejczyk, MD, PhD, Jerzy Jarząb,"— Presentation transcript:

1 Efficacy and safety of birch pollen immunotherapy for local allergic rhinitis 
Andrzej Bożek, MD, PhD, Krzysztof Kołodziejczyk, MD, PhD, Jerzy Jarząb, MD, PhD  Annals of Allergy, Asthma & Immunology  Volume 120, Issue 1, Pages (January 2018) DOI: /j.anai Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

2 Figure 1 Number of participants assessed for eligibility who completed the study. SLIT, sublingual immunotherapy. Annals of Allergy, Asthma & Immunology  , 53-58DOI: ( /j.anai ) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

3 Figure 2 The birch spore count and the weekly average of the symptom and medication scores (SMSs) recorded by patients in the active and placebo groups during pollen season in southern Poland in 2016 (after 2 years of allergan immunotherapy [AIT]). *P < .05. Annals of Allergy, Asthma & Immunology  , 53-58DOI: ( /j.anai ) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

4 Figure 3 Clinical efficacy of allergan immunotherapy (AIT) after 2 years of AIT compared with placebo. AAdSS, average adjusted symptom score; birch_2014, birch pollen season of 2014 (baseline); birch_2015, birch pollen season of 2015 (first year of AIT); birch_2016, birch pollen season of 2016 (second year of AIT), *P < .05. Annals of Allergy, Asthma & Immunology  , 53-58DOI: ( /j.anai ) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

5 Figure 4 (A) Serum concentrations of allergen-specific immunoglobulin E (IgE) to Bet v 1. (B) Serum concentrations of allergen-specific IgG4 to Bet v 1 during the study period: 2014 birch pollen season (baseline); 2015 season (first year of allergan immunotherapy [AIT]); 2016 season (second year of AIT). (C) Nasal concentration comparison of the IgE to Bet v 1 ratio during the study period. *P < .05. Annals of Allergy, Asthma & Immunology  , 53-58DOI: ( /j.anai ) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

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