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Figure 1. Structures of Tafluprost and four related impurities.

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Presentation on theme: "Figure 1. Structures of Tafluprost and four related impurities."— Presentation transcript:

1 Figure 1. Structures of Tafluprost and four related impurities.
From: Development of Novel RP-HPLC Method for Separation and Estimation of Critical Geometric Isomer and Other Related Impurities of Tafluprost Drug Substance and Identification of Major Degradation Compounds by Using LC–MS J Chromatogr Sci. 2016;54(8): doi: /chromsci/bmw086 J Chromatogr Sci | © The Author Published by Oxford University Press. All rights reserved. For Permissions, please

2 Figure 2. Origin of impurities and degradation pathway of acid and base degradations.
From: Development of Novel RP-HPLC Method for Separation and Estimation of Critical Geometric Isomer and Other Related Impurities of Tafluprost Drug Substance and Identification of Major Degradation Compounds by Using LC–MS J Chromatogr Sci. 2016;54(8): doi: /chromsci/bmw086 J Chromatogr Sci | © The Author Published by Oxford University Press. All rights reserved. For Permissions, please

3 Figure 3. Tafluprost related substances method
Figure 3. Tafluprost related substances method. (A) The chromatogram of Tafluprost spiked with its four impurities in the related substances method. (B) The acid degradation chromatogram of the related substances method. (C) The base degradation chromatogram of the related substances method. From: Development of Novel RP-HPLC Method for Separation and Estimation of Critical Geometric Isomer and Other Related Impurities of Tafluprost Drug Substance and Identification of Major Degradation Compounds by Using LC–MS J Chromatogr Sci. 2016;54(8): doi: /chromsci/bmw086 J Chromatogr Sci | © The Author Published by Oxford University Press. All rights reserved. For Permissions, please

4 Figure 4. Tafluprost assay method
Figure 4. Tafluprost assay method. (A) Tafluprost spiked with known impurities in assay method. (B) Tafluprost typical chromatogram of assay method. (C) Acid degradation chromatogram of the assay method. (D) Peroxide degradation chromatogram of the assay method. From: Development of Novel RP-HPLC Method for Separation and Estimation of Critical Geometric Isomer and Other Related Impurities of Tafluprost Drug Substance and Identification of Major Degradation Compounds by Using LC–MS J Chromatogr Sci. 2016;54(8): doi: /chromsci/bmw086 J Chromatogr Sci | © The Author Published by Oxford University Press. All rights reserved. For Permissions, please

5 Figure 5. LC–MS pattern of degradation samples
Figure 5. LC–MS pattern of degradation samples. (A) Acid degradation LC–MS. (B) Base degradation LC–MS (acid impurity identification). (C) Base degradation LC–MS (0.68 RRT impurity identification). From: Development of Novel RP-HPLC Method for Separation and Estimation of Critical Geometric Isomer and Other Related Impurities of Tafluprost Drug Substance and Identification of Major Degradation Compounds by Using LC–MS J Chromatogr Sci. 2016;54(8): doi: /chromsci/bmw086 J Chromatogr Sci | © The Author Published by Oxford University Press. All rights reserved. For Permissions, please

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