1. Chronic lymphocytic leukemia (CLL)
Presented by :
Sondos AbdAllah

2. Leukemia :
Cancer of the blood that develops from an over production of immature WBCs. As they accumulate, they interfere
with the vital organs functions, including the production of healthy BCs.

3. Chronic lymphocytic leukemia:
Cancer that affects a type of WBCs called a “lymphocyte”.
Lymphocytes help the body fight infections. they are made in the bone marrow.
CLL makes an abnormally high number of lymphocyte that aren’t working right.

4. More Adult get CLL than any other type of leukemia.
It’s more common in adult and elderly people than children.
It presents 25-30% of leukemias

5. Etiology:
Unknown. No causal relationship with radiation, chemicals or viruses.
Small proportional familial ;
lymphoid organs malignancies in the first degree.
Relatives with CLL in the second degree.

6. Symptoms:
70-80% asymptomatic. The disease grows so the patient may not have symptoms for several years. Others may have :
Lymphocytosis
Recurrent infections

7. In Advanced stages;
Lymphadenopathy; painless

8. Hepatosplenomegaly
Ultimatly, bone marrow failure leads to anemia, neutropenia and thrombocytopenia.

9. Investigations: CBC Immunopheontyping FISH Flow cytometry
IgVH gene mutation test
Bone marrow aspiration and biopsy
Direct antiglobulin test
Ultrasound

10. Treatment:
In early stages, CLL don’t needs treatment, it doesn’t help.
But it should be followed. If you noticed any change like the number of lymphocyte in blood growing quickly or more swelling in lymph nodes.

11. In advanced stages, we use:
chemotherapy
immunotherapy
radiation therapy
second line therapy
surgery by stem cells transplantation

12. “Cancer can take away all of my physical abilities
“Cancer can take away all of my physical abilities. It cannot touch my mind, it cannot touch my heart, and it cannot touch my soul.” – Jim Valvano

13.  For more information, see the following:
Leukemia Home Page
What You Need to Know About™ Leukemia
Drugs Approved for Chronic Lymphocytic Leukemia
Targeted Cancer Therapies
Biological Therapies for Cancer
BSH
Oxford handbook of hematology
Pubmed leukemia
Webmd leukemia

14. For general cancer information, see the following:
Staging
Chemotherapy and You: Support for People With Cancer
Radiation Therapy and You: Support for People With Cancer
Coping with Cancer
Questions to Ask Your Doctor about Cancer
For Survivors and Caregivers

15. THANK YOU !