1. Chromosomal Mutations

2. Chromosomal Mutations
Affects an entire chromosome or chromosomes
Typically occur during meiosis (gamete formation) but can also occur during mitosis
Can lead to cancer some cases
We will look at: Translocation, Deletion, Duplication and Inversion
Few harmful gene mutations are passed on to the next generation because the zygote usually dies. If it lives, the offspring may have birth defects.

3. Deletion of part of a chromosome - Genetic Material Breaks Off
A B C D E F G H
A B C E F G H
Gene “D” has been deleted

4. Duplication of Part of a Chromosome – Extra Copies of a Gene are Generated
B and C were duplicated
A B C D E F G H
A B C B C D E F G H

5. Inversion - Part of A Chromosome Breaks Off and Reattaches Backwards
B, C and D Inverted to Become D, C and B
A B C D E F G H
A D C B E F G H

6. Translocation - Part of One Chromosome Breaks Off and Attaches to a Different ChromosomeG H W X A B C D E F G H W X Y Z Y Z
Translocation OR Or