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Adsorption and function of recombinant Factor VIII at the air–water interface in the presence of Tween 80  Omkar Joshi, Liping Chu, Joseph McGuire, D.Q.

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Presentation on theme: "Adsorption and function of recombinant Factor VIII at the air–water interface in the presence of Tween 80  Omkar Joshi, Liping Chu, Joseph McGuire, D.Q."— Presentation transcript:

1 Adsorption and function of recombinant Factor VIII at the air–water interface in the presence of Tween 80  Omkar Joshi, Liping Chu, Joseph McGuire, D.Q. Wang  Journal of Pharmaceutical Sciences  Volume 98, Issue 9, Pages (September 2009) DOI: /jps.21569 Copyright © 2010 Wiley-Liss, Inc. Terms and Conditions

2 Figure 1 Surface tension kinetics exhibited by rFVIII–Tween mixtures as a function of Tween concentration. rFVIII concentration is 24.5 µg/mL in each case. Journal of Pharmaceutical Sciences  , DOI: ( /jps.21569) Copyright © 2010 Wiley-Liss, Inc. Terms and Conditions

3 Figure 2 Steady state values of surface tension recorded for rFVIII–Tween mixtures plotted as a function of Tween concentration. The regions I–V are indicated based on trends empirically observed for simple protein–surfactant mixtures. Journal of Pharmaceutical Sciences  , DOI: ( /jps.21569) Copyright © 2010 Wiley-Liss, Inc. Terms and Conditions

4 Figure 3 Surface tension kinetics exhibited by Tween as a function of concentration. Journal of Pharmaceutical Sciences  , DOI: ( /jps.21569) Copyright © 2010 Wiley-Liss, Inc. Terms and Conditions

5 Figure 4 Steady state values of surface tension recorded for rFVIII–Tween mixtures as compared with protein-free solutions containing Tween as the only surface active species. Journal of Pharmaceutical Sciences  , DOI: ( /jps.21569) Copyright © 2010 Wiley-Liss, Inc. Terms and Conditions

6 Figure 5 Turbidity (A350 nm) data recorded for agitated rFVIII samples. Journal of Pharmaceutical Sciences  , DOI: ( /jps.21569) Copyright © 2010 Wiley-Liss, Inc. Terms and Conditions

7 Figure 6 Wavelength at maximum fluorescence emission recorded for rFVIII–Tween samples (a) exposed to the air–water interface through agitation, and (b) stored at room temperature without agitation. Journal of Pharmaceutical Sciences  , DOI: ( /jps.21569) Copyright © 2010 Wiley-Liss, Inc. Terms and Conditions

8 Figure 7 Normalized fluorescence intensity at 334 nm for (a) agitated, and (b) unagitated rFVIII–Tween samples. Journal of Pharmaceutical Sciences  , DOI: ( /jps.21569) Copyright © 2010 Wiley-Liss, Inc. Terms and Conditions

9 Figure 8 Biological activity of Tween-containing rFVIII samples upon exposure to the air–water interface through agitation, and stored at room temperature without agitation. Journal of Pharmaceutical Sciences  , DOI: ( /jps.21569) Copyright © 2010 Wiley-Liss, Inc. Terms and Conditions

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