Presentation is loading. Please wait.

Presentation is loading. Please wait.

Solvent-Mediated Solid Phase Transformations of cArbamazepine: Effects of Simulated Intestinal Fluid and Fasted State Simulated Intestinal Fluid  Paula.

Published byJuuso Hakola Modified over 6 years ago

Similar presentations

Presentation on theme: "Solvent-Mediated Solid Phase Transformations of cArbamazepine: Effects of Simulated Intestinal Fluid and Fasted State Simulated Intestinal Fluid  Paula."— Presentation transcript:

1 Solvent-Mediated Solid Phase Transformations of cArbamazepine: Effects of Simulated Intestinal Fluid and Fasted State Simulated Intestinal Fluid  Paula Lehto, Jaakko Aaltonen, Mikko Tenho, Jukka Rantanen, Jouni Hirvonen, Veli Pekka Tanninen, Leena Peltonen  Journal of Pharmaceutical Sciences  Volume 98, Issue 3, Pages (March 2009) DOI: /jps.21490 Copyright © 2009 Wiley-Liss, Inc. Terms and Conditions

2 Figure 1 Raman spectra of (a) calibration samples and measured during the dissolution in (b) SIF and in (c) FaSSIF. The test peak (1023–1044cm−1) and the reference peak (1000–1044cm−1) used in the quantification are illustrated. Journal of Pharmaceutical Sciences  , DOI: ( /jps.21490) Copyright © 2009 Wiley-Liss, Inc. Terms and Conditions

3 Figure 2 X-ray diffractograms of (a) dry CBZ form III compact, (b) dry CBZ dihydrate compact and CBZ form III compacts after 19h of dissolution (c) in SIF and (d) in FaSSIF. Characteristic CBZ form III peaks at 13.1, 15.4, 15.9, and 17.2° (2θ) are indicated by asterisk (*) in the diffractograms c and d. Journal of Pharmaceutical Sciences  , DOI: ( /jps.21490) Copyright © 2009 Wiley-Liss, Inc. Terms and Conditions

4 Figure 3 Intrinsic dissolution results of CBZ form III compacts in SIF. (a) Amount of dissolved material (mgcm−2) of CBZ form III and (b) dissolution rate (mgcm−2h−1). The dissolved material of CBZ dihydrate compacts is presented as a reference. Journal of Pharmaceutical Sciences  , DOI: ( /jps.21490) Copyright © 2009 Wiley-Liss, Inc. Terms and Conditions

5 Figure 4 Scanning electron micrographs taken off-line of the CBZ form III compact's surfaces (a–c) before and after 4 and 14h into the dissolution testing in SIF, and (d–f) before and after 2 and 6h dissolution in FaSSIF. Journal of Pharmaceutical Sciences  , DOI: ( /jps.21490) Copyright © 2009 Wiley-Liss, Inc. Terms and Conditions

6 Figure 5 Solid phase conversion results obtained during the intrinsic dissolution tests of CBZ form III compacts in SIF. (a) Amount of dihydrate (%) and (b) conversion rate (%/h). Journal of Pharmaceutical Sciences  , DOI: ( /jps.21490) Copyright © 2009 Wiley-Liss, Inc. Terms and Conditions

7 Figure 6 Intrinsic dissolution results of CBZ form III compacts in FaSSIF. (a) Amount of dissolved material (mgcm−2) of CBZ form III and (b) dissolution rate (mgcm−2h−1). The dissolved material of CBZ dihydrate compacts is presented as a reference. Journal of Pharmaceutical Sciences  , DOI: ( /jps.21490) Copyright © 2009 Wiley-Liss, Inc. Terms and Conditions

8 Figure 7 Solid phase conversion results obtained during the intrinsic dissolution tests of CBZ form III compacts in FaSSIF. (a) Amount of dihydrate (%) and (b) conversion rate (%/h). Journal of Pharmaceutical Sciences  , DOI: ( /jps.21490) Copyright © 2009 Wiley-Liss, Inc. Terms and Conditions

9 Figure 8 (a) Structure of a needle-shaped crystal of CBZ dihydrate (=D) with the unit cell. (b) Orientation of CBZ molecules towards the crystal plane (−111). (c) Possible hydrogen bonds will form between (1) (left) oxygen of the sulphonate group (STC) and hydrogen of the amino group (CBZ) and (2) (right) hydrogen of the hydroxyl group (STC) and oxygen of the carbonyl group (CBZ; colors: red=oxygen, light gray/white=hydrogen). Journal of Pharmaceutical Sciences  , DOI: ( /jps.21490) Copyright © 2009 Wiley-Liss, Inc. Terms and Conditions

Download ppt "Solvent-Mediated Solid Phase Transformations of cArbamazepine: Effects of Simulated Intestinal Fluid and Fasted State Simulated Intestinal Fluid  Paula."

Similar presentations

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages 241-253 (March 2014) DOI: 10.1016/j.cell.2014.02.012 Copyright.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages 275-291 (March 2014) DOI: 10.1016/j.stem.2014.02.006.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages 255-266 (March 2014) DOI: 10.1016/j.cell.2014.03.012.

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell
ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.
IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages 389-391 (October.

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.
Mesoscale Simulation of Blood Flow in Small Vessels Prosenjit Bagchi Biophysical Journal Volume 92, Issue 6, Pages 1858-1877 (March 2007) DOI: 10.1529/biophysj.106.095042.

Mesoscale Simulation of Blood Flow in Small Vessels Prosenjit Bagchi Biophysical Journal Volume 92, Issue 6, Pages (March 2007) DOI: /biophysj
2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages 332-384 (March.

2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.
2002 Air Medical Transport Industry Awards Air Medical Journal Volume 22, Issue 2, Pages 16-18 (March 2003) DOI: 10.1016/S1067-991X(03)70032-7 Copyright.

2002 Air Medical Transport Industry Awards Air Medical Journal Volume 22, Issue 2, Pages (March 2003) DOI: /S X(03) Copyright.
Image Postprocessing in Digital Radiology—A Primer for Technologists Euclid Seeram, RTR, BSc, MSc, FCAMRT, David Seeram Journal of Medical Imaging and.

Image Postprocessing in Digital Radiology—A Primer for Technologists Euclid Seeram, RTR, BSc, MSc, FCAMRT, David Seeram Journal of Medical Imaging and.
Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages 305-320 (March 2005) DOI: 10.1016/j.devcel.2005.02.007.

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel
Inbreeding in Danish Dairy Cattle Breeds A.C. Sørensen, M.K. Sørensen, P. Berg Journal of Dairy Science Volume 88, Issue 5, Pages 1865-1872 (May 2005)

Inbreeding in Danish Dairy Cattle Breeds A.C. Sørensen, M.K. Sørensen, P. Berg Journal of Dairy Science Volume 88, Issue 5, Pages (May 2005)
Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism ‐ Based Prediction of Volume of Distribution Patrick Poulin, Frank ‐ Peter Theil.

Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism ‐ Based Prediction of Volume of Distribution Patrick Poulin, Frank ‐ Peter Theil.
Fasted-State Simulated Intestinal Fluid FaSSIF-C, a Cholesterol Containing Intestinal Model Medium for In Vitro Drug Delivery Development  Pooneh Khoshakhlagh,

Fasted-State Simulated Intestinal Fluid "FaSSIF-C", a Cholesterol Containing Intestinal Model Medium for In Vitro Drug Delivery Development  Pooneh Khoshakhlagh,
Optimization of Storage Stability of Lyophilized Actin Using Combinations of Disaccharides and Dextran  S.Dean Allison, Mark C. Manning, Theodore W. Randolph,

Optimization of Storage Stability of Lyophilized Actin Using Combinations of Disaccharides and Dextran  S.Dean Allison, Mark C. Manning, Theodore W. Randolph,
Application of Powder X-ray Diffraction in Studying the Compaction Behavior of Bulk Pharmaceutical Powders  Rebanta Bandyopadhyay, Jon Selbo, Gregory.

Application of Powder X-ray Diffraction in Studying the Compaction Behavior of Bulk Pharmaceutical Powders  Rebanta Bandyopadhyay, Jon Selbo, Gregory.
Evaluation of Indomethacin Percutaneous Absorption from Nanostructured Lipid Carriers (NLC): In Vitro and In Vivo Studies  Maurizio Ricci, Carmelo Puglia,

Evaluation of Indomethacin Percutaneous Absorption from Nanostructured Lipid Carriers (NLC): In Vitro and In Vivo Studies  Maurizio Ricci, Carmelo Puglia,
Preparation of budesonide/γ‐cyclodextrin complexes in supercritical fluids with a novel SEDS method  Tarja Toropainen, Sitaram Velaga, Teemu Heikkilä,

Preparation of budesonide/γ‐cyclodextrin complexes in supercritical fluids with a novel SEDS method  Tarja Toropainen, Sitaram Velaga, Teemu Heikkilä,
Stabilization of Lysozyme by Benzyl Alcohol: Surface Tension and Thermodynamic Parameters  Monu Kumari Goyal, Ipsita Roy, Aeshna Amin, Uttam Chand Banerjee,

Stabilization of Lysozyme by Benzyl Alcohol: Surface Tension and Thermodynamic Parameters  Monu Kumari Goyal, Ipsita Roy, Aeshna Amin, Uttam Chand Banerjee,
Preparation of budesonide/γ‐cyclodextrin complexes in supercritical fluids with a novel SEDS method  Tarja Toropainen, Sitaram Velaga, Teemu Heikkilä,

Preparation of budesonide/γ‐cyclodextrin complexes in supercritical fluids with a novel SEDS method  Tarja Toropainen, Sitaram Velaga, Teemu Heikkilä,
Stabilization of Low Glass Transition Temperature Indomethacin Formulations: Impact of Polymer-Type and Its Concentration  Rina J. Chokshi, Navnit H.

Stabilization of Low Glass Transition Temperature Indomethacin Formulations: Impact of Polymer-Type and Its Concentration  Rina J. Chokshi, Navnit H.

Similar presentations

Ads by Google