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Comparison of a Miniaturized Shake-Flask Solubility Method with Automated Potentiometric Acid/Base Titrations and Calculated Solubilities  A. Glomme,

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Presentation on theme: "Comparison of a Miniaturized Shake-Flask Solubility Method with Automated Potentiometric Acid/Base Titrations and Calculated Solubilities  A. Glomme,"— Presentation transcript:

1 Comparison of a Miniaturized Shake-Flask Solubility Method with Automated Potentiometric Acid/Base Titrations and Calculated Solubilities  A. Glomme, J. März, J.B. Dressman  Journal of Pharmaceutical Sciences  Volume 94, Issue 1, Pages 1-16 (January 2005) DOI: /jps.20212 Copyright © 2004 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

2 Figure 1 Potentiometric titration curve of mefenamic acid, measured with the pSol instrument at 37°C. Journal of Pharmaceutical Sciences  , 1-16DOI: ( /jps.20212) Copyright © 2004 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

3 Figure 2 Bjerrum plot of mefenamic acid measured with the pSol instrument at 37°C. Journal of Pharmaceutical Sciences  , 1-16DOI: ( /jps.20212) Copyright © 2004 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

4 Figure 3 (a) Schematic of Whatman Processor™. (b) Photograph of Whatman Processor™. Journal of Pharmaceutical Sciences  , 1-16DOI: ( /jps.20212) Copyright © 2004 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

5 Figure 4 (a) Schematic of pSol instrument (Sirius‐Analytics, Riverside, UK). (b) Photograph of pSol instrument. Journal of Pharmaceutical Sciences  , 1-16DOI: ( /jps.20212) Copyright © 2004 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

6 Figure 5 Solubility determinations of glyburide with the pSol instrument using ACN as cosolvent. Journal of Pharmaceutical Sciences  , 1-16DOI: ( /jps.20212) Copyright © 2004 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

7 Figure 6 Solubility determinations of glyburide with the pSol instrument using methanol as cosolvent. Journal of Pharmaceutical Sciences  , 1-16DOI: ( /jps.20212) Copyright © 2004 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

8 Figure 7 pH/solubility profile for glyburide, determined with the miniaturized shake‐flask method (▴) and the pSol instrument (×). Journal of Pharmaceutical Sciences  , 1-16DOI: ( /jps.20212) Copyright © 2004 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

9 Figure 8 Correlation between measured (miniaturized shake‐flask) and solubilities calculated with WSKOWWIN version 1.40 with calculated logP and mp (▴) and experimental logP and mp (+). Journal of Pharmaceutical Sciences  , 1-16DOI: ( /jps.20212) Copyright © 2004 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

10 Figure 9 Correlation between the measured (miniaturized shake‐flask) solubilities with those calculated with the WSKOWWIN version 1.40 program (+), and with the Yalkowsky equation (). Journal of Pharmaceutical Sciences  , 1-16DOI: ( /jps.20212) Copyright © 2004 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

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