1. Volume 44, Issue 7, Pages 1310-1319 (July 2013)
Genetic clonal mapping of in situ and invasive ductal carcinoma indicates the field cancerization phenomenon in the breast 
Maria P. Foschini, MD, Luca Morandi, PhD, Elisa Leonardi, PhD, Federica Flamminio, MD, Yuko Ishikawa, MD, PhD, Riccardo Masetti, MD, Vincenzo Eusebi, MD, FRCPath 
Human Pathology 
Volume 44, Issue 7, Pages (July 2013)
DOI: /j.humpath
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2. Fig. 1
Case 3: well differentiated DCIS. M1 and M2 are the areas of the microdissected in situ lesions, 46 mm apart. DCIS in M1 and M2 do not appear clonal in the phylogenetic tree as they are located in a different root branch. M3 and M4 are the microdissected areas of the invasive lesions on the contralateral breast. All contralateral lesions (DCIS, IDCs and LN MTS) are not related to the above DCIS lesions but are clonally related each other. Abbreviations: M, area of microdissection; DCIS, ductal carcinoma in situ; CLT, contralateral; IDC, invasive duct carcinoma; LN MTS, lymph node metastases; REF, reference tissue.
Human Pathology  , DOI: ( /j.humpath )
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3. Fig. 2
Case 6: DCIS with intermediate differentiation. M1 and M2 are the areas of the microdissected in situ lesions, 72 mm apart. DCIS in M1 and M2 do not appear clonal in the phylogenetic tree as they are located in a different root branch. The contralateral IDC is not related to the above neoplastic lesions. Abbreviations: M, area of microdissection; CLT, contralateral; REF, reference tissue.
Human Pathology  , DOI: ( /j.humpath )
Copyright © 2013 Elsevier Inc. Terms and Conditions

4. Fig. 3
Case 11: poorly differentiated DCIS. M1 and M2 are the areas of the microdissected in situ lesions, 30 mm apart. An area of g3 IDC (M3) is not included in the picture as it was present in another quadrant. DCIS in M1 and M2 appear clonal in the phylogenetic tree as they cluster in the same branch. IDC as well as LN metastases appear located in a different root branch. They are related each other, but not related to the in situ lesions. Abbreviations: M, area of microdissection; DCIS, ductal carcinoma in situ; IDC, invasive duct carcinoma; LN MTS, lymph node metastases; REF, reference tissue.
Human Pathology  , DOI: ( /j.humpath )
Copyright © 2013 Elsevier Inc. Terms and Conditions

5. Supplementary Fig. 1.
Cases 1, 2, 4, 5: phylogenetic trees of g1 DCIS cases.
Human Pathology  , DOI: ( /j.humpath )
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6. Supplementary Fig. 2.
Cases 7, 8, 9, 10: phylogenetic trees of g2 DCIS cases.
Human Pathology  , DOI: ( /j.humpath )
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7. Supplementary Fig. 3.
Cases 12, 13, 14, 15: phylogenetic trees of g3 DCIS cases.
Human Pathology  , DOI: ( /j.humpath )
Copyright © 2013 Elsevier Inc. Terms and Conditions