1. Performance of first trimester fetal anomaly scan: Single center results of six years
Erol Arslan, Selim Buyukkurt, Mete Sucu, Selahattin Misirlioglu, Mehmet Ozsurmeli, Suleyman Cansun Demir, Ismail Cuneyt Evruke

2. Aim/Background First trimester ultrasound……Aneuploidy Screening
Second trimester ultrasound……Fetal Anatomy Screening

3. Aim/Background
Question 1: Can first trimester ultrasound be used for early anomaly detection?????
If so, which kind of anomalies can be detected in early ultrasound examination?

4. Material and Method Retrospective
Terminated single pregnancies due to fetal anomalies detected at and before 15+6 weeks
From 2011 to 2016
Two groups: and
Statistical Method: Fisher’s Exact Test

5. Material and Method Excluded ultrasonographic findings:
Thickened nuchal translucency
Tricuspid regurgitation
A wave on ductus venosus doppler

6. Results In total 244 pregnancies were terminated
109 terminated during (group 1)
135 terminated during (group 2)
24% increase in diagnosed patients in group 2 comparing group 1

7. Results In total 287 anomalies were detected 121 were in group 1
37% increase in detected anomalies in group 2 comparing group 1

8.
Cranial NTD 45 44
Spina bifida 5 4
Sacrococcygeal teratoma 1
Holoprosencephaly 3 6
Ventriculomegaly
Cerebellar hypoplasia 2
AVSD
Hypoplastic left ventricle
Cystic hygroma 24 38
Hydrops fetalis 13 7
Micrognathia
Nasal hypoplasia 9
Multicystic dysplastic kidney
Renal agenesis
Megacystitis
Abdominal wall defects 10 17
Skeletal dysplasia
Intestinal obstruction

9. Results
The percentage of acrania/anencephaly and hydrops/non-hydrops fetalis in all anomalies were significantly higher in group 1.
The percentage of AVSD and nasal bone hypoplasia in all anomalies were significantly higher in group 2.

10. Discussion
A data of eight centers from 36,237 pregnancies showed a 29% detection rate of fetal anomalies during first trimester screening.
A. Borrell et. All Clinical value of the 11 to 13+6 weeks sonogram for detection of congenital malformations: a review Am J Perinatol, 28 (2011),

11. Discussion
In another review the highest rate was found for thorax/ abdomen group excluding cardiac defect and it was followed by central nervous system group.
The detection rate of cardiac defect was 20%
Harm-Gerd Karl Blaas, Detection of structural abnormalities in the first trimester using ultrasound

12. Discussion
Whereas first trimester screening getting popular in developed countries, it is mostly using for aneuploidy screening in our country.
Still most of the detected anomalies in first trimester were acrania/anencephaly and cystic hygroma in our study.
Against it our diagnostic performance for specific anomalies like AVSD was improved

13. Conclusion
During fetal aneuploidy screening in first trimester a meticulous examination can reveal major fetal abnormalities
Early detection may make easier the termination for family.