1. Irritation fibroma

2. Irritation fibroma the most common "tumor" of the oral cavity.
However, it is doubtful that it represents a true neoplasm in most instances
rather, it is a reactive hyperplasia of fibrous connective tissue in response to local irritation or trauma.
the most common location is the buccal mucosa along the bite line.
The labial mucosa, tongue, and gingiva also are common sites

3. Irritation fibromas are self-limiting, slow growing generally asymptomatic masses of mature dense sparsely cellular fibrous connective tissue
result from low intensity, prolonged chronic irritation.
A small, firm sessile swelling in the buccal mucosa near the commissure. The pale color without increased vascularity
result from trauma during biting.

4. a broad base (sessile) and is covered by the typically intact mucosa.
Most fibromas are sessile, although some are pedunculated
a broad base (sessile) and is covered by the typically intact mucosa.
somewhat less common on the lip as compared to the buccal mucosa.
generally asymptomatic.

5. This somewhat polypoid mass on the lateral border of the tongue shows increased vascularity but is still covered by intact mucosa.
Excisional biopsy is the method of diagnosis and treatment.

6. a moderate sized typical appearing irritation fibrosis.
When they reach this size the lesions are more likely to be irritated……… causing increase in growth; a vicious cycle is initiated.
the general practitioner can easily remove lesions of this type when they occur on the buccal mucosa.

7. an excisional biopsy of a lesion
The cut surface reveals homogeneous dense white collagen.

8. Histopathologic Features

9. a nodular non-encapsulated lesion generally covered by intact but somewhat thin squamous epithelium.
the fairly dense fibrous tissue extending into the submucosal area.

10. Irritation Fibroma
the extremely dense wavy collagen bundles containing few fibroblasts.
little or no inflammation the epi.is intact.

11. At high-power
extremely broad collagen bundles with a small blood vessel in the central portion.
Spindle-shaped fibroblasts are sparse and there is no inflammation.
If this were a true fibroma or neoplasm of fibroblasts …………………………………many cells and much less collagen
Although prognosis is excellent, there may be recurrence if local irritating factors remain

12. Low-power
a dome-shaped lesion consisting of an increased amount of dense connective tissue.

13. a dense connective tissue with collagen bundles and relatively few blood vessels and fibroblasts.

14. A dense connective tissue.

15. Irritation Fibroma 2 1
1-Fibrosis
2-Epithelial acanthosis

16. Irritation Fibroma
Epithelial Atrophy(arrow)

17. Irritation Fibroma
Epithelial acanthosis

18. True Fibroma 1-Fibrin coverage 2-Granulation tissue 3-Fibroblasts 1 3

19. True Fibroma
Proliferation of Fibroblasts

20. The end