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Expression of follicular cell‐derived VEGF‐A and endothelial VEGFR is altered by different circulating TSH level Expression of follicular cell‐derived.

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Presentation on theme: "Expression of follicular cell‐derived VEGF‐A and endothelial VEGFR is altered by different circulating TSH level Expression of follicular cell‐derived."— Presentation transcript:

1 Expression of follicular cell‐derived VEGF‐A and endothelial VEGFR is altered by different circulating TSH level Expression of follicular cell‐derived VEGF‐A and endothelial VEGFR is altered by different circulating TSH level AImages showing X‐gal‐stained VEGF‐A in the thyroid glands of VEGF‐A+/LacZ mice.B–DComparisons of VEGF‐A mRNA and protein levels in thyroid glands, and circulating VEGF‐A levels in serum.EPhase contrast image of cultured rat thyroid follicular cell line, FRTL‐5.FIncreases of VEGF‐A mRNA expression in FRTL‐5 cells at 3 h after TSH stimulation.GComparisons of VEGF‐A mRNA levels in FRTL‐5 cells after supplement with cell signal inhibitors. Cells were pretreated for 1 h with KT5720 (KT, 3 μM), Go6976 (Go, 0.1 μM), or LY (LY, 20 μM) before TSH (1 mU/ml) supplementation.HImages showing X‐gal‐stained VEGFR2 in the thyroid glands of VEGFR2+/LacZ mice.I, JImmunofluorescence images showing expression of VEGFR2 and VEGFR3.KComparisons of VEGFR2 and VEGFR3 mRNA levels.LComparisons of expression of VEGFR2 and VEGFR3 (relative percentage to the levels of CD31) proteins.Data information: Each group, n = 4 in (B, C, D, K, and L). Each group, n = 3 in (F and G). Error bars represent mean ± s.d. Kruskal–Wallis test followed by Tukey's multiple comparison test was used in (B, C, D, F, K, and L). Mann–Whitney U‐test was used in (G). ns, not significant. Scale bars, 50 μm. Jeon Yeob Jang et al. EMBO Mol Med. 2017;9: © as stated in the article, figure or figure legend

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