1. Manar hajeer,MD, FRCPath
Heart Diseases
Manar hajeer,MD, FRCPath

2. Left-Sided Heart Failure
Causes:
Ischemic heart disease (IHD),
Systemic hypertension,
Mitral or aortic valve disease.
Diseases of myocardium.

3. Clinical Features
a. Dyspnea on exertion is the earliest and most significant symptom
b. Cough
c. Orthopnea: Dyspnea when recumbent occurs because the supine position increases venous return from the lower extremities and typically is relieved by sitting or standing,

4. d. Paroxysmal nocturnal dyspnea :dyspnea awakening patients from sleep with feelings of suffocation
e. Fine rales at the lung bases, caused by pulmonary edema.
f. Diminished cardiac output leads to decreased renal perfusion and diminished cerebral perfusion

5. II. Right-Sided Heart Failure
Usually is the consequence of left-sided heart failure.
Causes of isolated right-sided heart failure
Severe pulmonary hypertension resulting in right-sided heart failure ( cor pulmonale).
b. Pulmonic or tricuspid valve disease.
c. Congenital left-to-right shunts.

6. Clinical Features
Related to systemic and portal venous congestion including congestive hepatomegaly and splenomegaly peripheral edema (ankle and pretibial) , pleural and pericardial effusion, and ascites.
In chronic cardiac decompensation, patients present with biventricular CHF encompassing syndromes of both right- sided and left-sided heart failure.

7. III. ISCHEMIC HEART DISEASE)(IHD)
- An imbalance between cardiac oxygen supply and myocardial demand.
- Called coronary artery disease (CAD)..
- In more than 90% of cases, IHD is due to reduced coronary blood flow secondary to obstructive atherosclerosis

8. The clinical presentation
Angina Pectoris :
Is an intermittent chest pain caused by transient, reversible myocardial ischemia.
II. Myocardial infarction.
III. Chronic ischemic heart disease.
IV. Sudden cardiac death.

9. Variants Typical or stable angina
is episodic chest pain associated with exertion or tachycardia and the pain is a crushing or squeezing substernal sensation, that can radiate to left arm or to the left jaw (referred pain) and usually is relieved by rest or by drugs (nitroglycerin), a vasodilator increases coronary perfusion.
- Is caused by fixed atherosclerotic lesion that occlude more than 70% of a vessel

10. Prinzmetal or variant angina -
Might be caused by vasospasm;

11. C- Unstable angina
- Called crescendo angina, it occurs at rest
Caused by fixed atherosclerotic lesion that occludes 90% of vessel lumen
It is often the harbinger of MI,

12. d. Myocardial Infarction (MI),
referred to as "heart attack,“ and means necrosis of heart muscle resulting from ischemia
MIs can occur at virtually any age but the frequency rises progressively with increasing age.
- Approximately 10% of MIs occur before age 40
- Men are at significantly greater risk than women, and women tend to be protected against MI during their reproductive years.

13. However, menopause women with declining estrogen is associated with exacerbation of coronary artery disease and IHD is the most common cause of death in elderly women.

14. Pathogenesis:
1. Caused by completely obstructive thrombus over a disrupted plaque can cause a massive MI.
In a majority of cases, the lesion in patients who suffer MI was not critically stenotic or symptomatic before its rupture.

15. Influences extrinsic to plaque are important.
Adrenergic stimulation put physical stress on the plaque by causing hypertension or vasospasm and the surge in adrenergic stimulation associated with awakening and rising may underlie that the incidence of acute MI is highest in early morning.

16. 2. In 10% of MIs, infarction occurs in the absence of occlusive atherosclerosis and such infarcts are mostly attributable to coronary artery vasospasm

17. - Some occlusions clear spontaneously through lysis of the thrombus
- Early thrombolysis can be successful in limiting the extent of myocardial necrosis

18. The sequence of changes in MI:
1.Loss of contractility occurs within a minute of onset of ischemia and may be reversible.
2. Severe ischemia lasting 20 to 40 minutes causes myocyte coagulative necrosis
.Note; Thus, if, myocardial blood flow is restored before irreversible injury ,cell viability can be preserved; and this is the rationale for early diagnosis of MI, and Intervention to salvage myocardium at risk.

19. 3. Although massive myocardial damage can cause fatal mechanical failure, in 80% to 90% of the cases , the death is due to ventricular fibrillation

20. Atherosclerotic narrowing can affect
1. Left anterior descending (LAD),
2. Left circumflex (LCX),
3. Right coronary artery (RCA)
Note: Clinically significant plaques tend to occur within the first several centimeters of the LAD and LCX, and along the entire length of the RCA.

21. The forms of MI may be
1. Transmural infarctions: Involve > 50% of the myocardial wall thickness.
2. Subendocardial infarctions : limited to the inner third of the myocardium;

22. Clinical Features
a. Severe crushing substernal chest pain that can radiate to the neck, epigastrium jaw, or left arm ,
- In 10% to 15%, MIs have may even be "silent" infarcts and particularly common in patients with diabetes mellitus
b. Rapid and weak pulse , nausea and sweating.
c. Dyspnea attributable to resultant acute pulmonary edema.

23. The laboratory evaluation of MI
- Based on measuring blood levels of macro -molecules that leak out of injured myocardial cells
- Cardiac troponins and CK-MB have high specificity and sensitivity for MI
- CK-MB remains a valuable marker of myocardial injury, second only to the cardiac-specific troponins

24. - Total CK activity is not a reliable marker of cardiac injury since various isoforms of CK are found in brain and skeletal muscle
The CK-MB isoform is the more specific indicator of heart damage and its activity begins to rise within 2 to 4 hours of MI, peaks at 24 to 48 hours, and returns to normal within 72 hours.

25. - TnI and TnT normally are not found in the circulation; however, after acute MI, both
are detectable within 2 to 4 hours, with levels peaking at 48 hours and remaining elevated for 7 to 10 days.

26. - Although cardiac troponin and CK-MB are sensitive markers of the early stages of an MI, persistence of elevated troponin levels for approximately 10 days allows the diagnosis of an acute MI long after CK-MB levels have returned to normal

27. Complications of Myocardial Infarction
Occur in Nearly three fourths of patients
1. Contractile dysfunction: In most cases of MI, there is some degree of left ventricular failure.
2, Cardiogenic shock due to pump failure occurs in 10% of patients with MIs and typically is associated with infarcts that damage 40% of the left ventricle
3. Papillary muscle dysfunction leads to post-infarct mitral regurgitation and it can result from post infarct ischemic dysfunction and later from muscle fibrosis and shortening .

28. 4 Myocardial rupture. :complicates 1% to 5% of MIs but is fatal when it occurs.
Left ventricular free wall rupture is most common, usually resulting in rapidly fatal hemopericardium and cardiac tamponade.

29. It occurs commonly within 3 to 7 days after infarction especially in females and age older than 60 years,
Other risk factors include anterior or lateral wall infarctions, and First MI (as scarring associated with prior MIs tends to limit the risk of myocardial tearing).

30. 5. Arrhythmias: due to myocardial irritability and conduction disturbances that can cause sudden death
- Approximately 90% of patients develop some form of rhythm disturbance,
The risk of ventricular fibrillation is greatest in the first hour and declines thereafter.

31. 6. Pericarditis. : manifested as anterior chest pain and a pericardial friction rub, and appears 2 to 3 days after infarction . Severe pericardial inflammation can lead to fibrosis to form dense adhesions that manifest as a constrictive lesion.

32. 7. Mural thrombus. Due to combination of stasis and endocardial damage
8.Ventricular aneurysm: is a late complication, and most commonly result from a large anteroseptal infarct that heals with the formation a thinned wall of scar tissue and usually do not rupture (since fibrotic)
9. Progressive late heart failure.