1. Date of download: 11/12/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Independent Components of Chronic Kidney Disease as a Cardiovascular Risk StateResults From the Kidney Early Evaluation Program (KEEP) Arch Intern Med. 2007;167(11):1122-1129. doi:10.1001/archinte.167.11.1122 Prevalence of self-reported cardiovascular disease (CVD) stratified by estimated glomerular filtration rate (eGFR) and microalbuminuria (MA) category (P =.41 for eGFR of <30, P<.001 for eGFR of 30-59, P<.001 for eGFR of 60-89, and P =.02 for eGFR of ≥90 mL/min per 1.73 m 2 ) (eGFR χ 2 = 508.21 and MA χ 2 = 71.35, P<.001 for trend for both). Figure Legend:

2. Date of download: 11/12/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Independent Components of Chronic Kidney Disease as a Cardiovascular Risk StateResults From the Kidney Early Evaluation Program (KEEP) Arch Intern Med. 2007;167(11):1122-1129. doi:10.1001/archinte.167.11.1122 Prevalence of self-reported cardiovascular disease (CVD) stratified by estimated glomerular filtration rate (eGFR) and hemoglobin (Hb) category (P =.95 for eGFR of <30, P =.008 for eGFR of 30-59, P =.02 for eGFR of 60-89, and P =.56 for eGFR of ≥90 mL/min per 1.73 m 2 ) (eGFR χ 2 = 614.95, P<.001 for trend; Hb χ 2 = 15.67, P =.001 for trend). Figure Legend:

3. Date of download: 11/12/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Independent Components of Chronic Kidney Disease as a Cardiovascular Risk StateResults From the Kidney Early Evaluation Program (KEEP) Arch Intern Med. 2007;167(11):1122-1129. doi:10.1001/archinte.167.11.1122 Prevalence of self-reported cardiovascular disease (CVD) stratified by microalbuminuria (MA) and hemoglobin (Hb) category (P30, P =.07 for MA of 21-30, P =.64 for MA of 11-20, and P =.05 for MA of ≤10 mg/L) (MA χ 2 = 117.49 and Hb χ 2 = 22.68, P<.001 for trend for both) Figure Legend:

4. Date of download: 11/12/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Independent Components of Chronic Kidney Disease as a Cardiovascular Risk StateResults From the Kidney Early Evaluation Program (KEEP) Arch Intern Med. 2007;167(11):1122-1129. doi:10.1001/archinte.167.11.1122 Prevalence of cardiovascular disease (CVD) in the subset of 2363 individuals with anemia (hemoglobin level of 50 years and <11.0 g/dL in women <51 years) and with microalbuminuria (≥20 mg/L) by estimated glomerular filtration rate (eGFR) groups (P<.001). Figure Legend:

5. Date of download: 11/12/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Independent Components of Chronic Kidney Disease as a Cardiovascular Risk StateResults From the Kidney Early Evaluation Program (KEEP) Arch Intern Med. 2007;167(11):1122-1129. doi:10.1001/archinte.167.11.1122 Kaplan-Meier curves for all-cause mortality stratified by no chronic kidney disease (CKD) or cardiovascular disease (CVD), CKD, CVD, and CVD plus CKD (follow-up from screening date to December 31, 2004; P<.001, log-rank test). Figure Legend:

6. Date of download: 11/12/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Independent Components of Chronic Kidney Disease as a Cardiovascular Risk StateResults From the Kidney Early Evaluation Program (KEEP) Arch Intern Med. 2007;167(11):1122-1129. doi:10.1001/archinte.167.11.1122 Kaplan-Meier curves for all-cause mortality grouped by 0, 1, 2, and 3 components of chronic kidney disease risk (components included anemia, microalbuminuria, and estimated glomerular filtration rate of <60 mL/min per 1.73 m 2 ) (follow-up from screening date to December 31, 2004; P<.001, log-rank test). Figure Legend: