1. Date of download: 6/25/2016 From: Blood Pressure and Mortality in U.S. Veterans With Chronic Kidney Disease: A Cohort Study Ann Intern Med. 2013;159(4):233-242. doi:10.7326/0003-4819-159-4-201308200-00004 Study flow diagram. BP = blood pressure; CKD = chronic kidney disease; eGFR = estimated glomerular filtration rate; ESRD = end-stage renal disease. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 6/25/2016 From: Blood Pressure and Mortality in U.S. Veterans With Chronic Kidney Disease: A Cohort Study Ann Intern Med. 2013;159(4):233-242. doi:10.7326/0003-4819-159-4-201308200-00004 Multivariable-adjusted relative hazards (hazard ratios [95% CIs]) of all-cause mortality associated with SBP and DBP relative to a hypothetical patient with the mean time-varying SBP (133 mm Hg) and DBP (71 mm Hg). Calculated in time-dependent Cox models using restricted cubic splines, adjusted for age, sex, race, diabetes mellitus, cardiovascular and cerebrovascular disease, chronic heart failure, Charlson Comorbidity Index scores, medication use (angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers; α-blockers, β-blockers, and calcium-channel blockers; loop and thiazide diuretics; and cholesterol-lowering agents), estimated glomerular filtration rates, and blood cholesterol levels. DBP = diastolic blood pressure; SBP = systolic blood pressure. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 6/25/2016 From: Blood Pressure and Mortality in U.S. Veterans With Chronic Kidney Disease: A Cohort Study Ann Intern Med. 2013;159(4):233-242. doi:10.7326/0003-4819-159-4-201308200-00004 Multivariable-adjusted relative hazards (hazard ratios [95% CIs]) of all-cause mortality associated with baseline SBP and DBP relative to a hypothetical patient with the mean SBP (135 mm Hg) and DBP (72 mm Hg). Calculated in Cox models using restricted cubic splines, adjusted for age, sex, race, diabetes mellitus, cardiovascular and cerebrovascular disease, chronic heart failure, Charlson Comorbidity Index scores, baseline medication use (angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers; α-blockers, β-blockers, and calcium-channel blockers; loop and thiazide diuretics; and cholesterol-lowering agents), baseline estimated glomerular filtration rates, and baseline blood cholesterol levels. DBP = diastolic blood pressure; SBP = systolic blood pressure. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 6/25/2016 From: Blood Pressure and Mortality in U.S. Veterans With Chronic Kidney Disease: A Cohort Study Ann Intern Med. 2013;159(4):233-242. doi:10.7326/0003-4819-159-4-201308200-00004 Multivariable-adjusted mortality hazard ratios (95% CIs) associated with blood pressure categories defined according to cutoffs established by the JNC 7. The group with systolic blood pressure <120 mm Hg and diastolic blood pressure <80 mm Hg served as reference. Estimates are from time-dependent Cox models adjusted for age, sex, race, diabetes mellitus, cardiovascular and cerebrovascular disease, chronic heart failure, Charlson Comorbidity Index scores, medication use (angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers; α-blockers, β-blockers, and calcium-channel blockers; loop and thiazide diuretics; and cholesterol-lowering agents), eGFRs, and blood cholesterol levels. CAD = coronary artery disease; CHF = chronic heart failure; eGFR = estimated glomerular filtration rate; HTN = hypertension; UACR = urinary microalbumin–creatinine ratio. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians