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Proteasome inhibition during myocardial infarction by Xichun Yu, and David C. Kem Cardiovasc Res Volume ():cvp309 October 4, 2009 Published on behalf of.

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Presentation on theme: "Proteasome inhibition during myocardial infarction by Xichun Yu, and David C. Kem Cardiovasc Res Volume ():cvp309 October 4, 2009 Published on behalf of."— Presentation transcript:

1 Proteasome inhibition during myocardial infarction by Xichun Yu, and David C. Kem Cardiovasc Res Volume ():cvp309 October 4, 2009 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

2 Proposed mechanisms for proteasome inhibition-mediated cardioprotection during acute myocardial ischaemia. Xichun Yu, and David C. Kem Cardiovasc Res 2009;cvr.cvp309 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

3 Potential therapeutic targets of the UPS. Ubiquitination is mediated by the sequential action of a multi-enzymatic system consisting of E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 (ubiquitin ligase). Xichun Yu, and David C. Kem Cardiovasc Res 2009;cvr.cvp309 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

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