1. Neuroanatomy Lectures Lecture 4 Cerebrum د. ليث ثامر خزعل

2. Cerebrum Subdivisions of the Cerebrum The cerebrum is the largest part of the brain, situated in the anterior and middle cranial fossae of the skull and occupying the whole concavity of the vault of the skull. It may be divided into two parts: the diencephalon, which forms the central core, and the telencephalon, which forms the cerebral hemispheres. The diencephalon consists of the third ventricle and the structures that form its boundaries It extends posteriorly to the point where the third ventricle becomes continuous with the cerebral aqueduct and anteriorly as far as the interventricular foramina Thus, the diencephalon is a midline structure with symmetrical right and left halves

4. Superior view of the cerebral hemispheres

5. Gross Features of diencephalon inferior surface The only area exposed to the surface in the intact brain. formed by hypothalamic and other structures, which include, from anterior to posterior, the optic chiasma, with the optic tract on either side; the infundibulum, with the tuber cinereum; and the mammillary bodies

6. superior surface of the diencephalon is concealed by the fornix Fornix is thick bundle of fibers that originates in the hippocampus of the temporal lobe and arches posteriorly over the thalamus to join the mammillary body Sup wall formed by roof of the third ventricle lateral surface of the diencephalon bounded by the internal capsule of white matter Medial surface Since the diencephalon is divided into symmetrical halves by the slitlike third ventricle, it also has a medial surface. The medial surface of the diencephalon (i.e., the lateral wall of the third ventricle) is formed in its superior part by the medial surface of the thalamus and in its inferior part by the hypothalamus, These two areas are separated from one another by a shallow sulcus, the hypothalamic sulcus

7. The diencephalon can be divided into four major parts: (1) the thalamus, (2) the subthalamus, (3) the epithalamus, (4) the hypothalamus

8. Inferior surface of the brain showing parts of the diencephalon

9. Sagittal section of the brain showing the medial surface of the diencephalon

10. Thalamus - a large ovoid mass of gray matter that forms the major part of the diencephalon It is a region of great functional importance and serves as a cell station to all the main sensory systems (except the olfactory pathway) - The activities of the thalamus are closely related to that of the cerebral cortex and damage to the thalamus causes great loss of cerebral function - pulvinar: is the expanded posterior end of the thalamus - lateral geniculate body: a small elevation on the under aspect of the lateral portion of the pulvinar The thalamus contain many important nuclei that will be discussed in future

11. As a relation, superior surface is covered medially by the tela choroidea and the fornix, and laterally, it is covered by ependyma and forms part of the floor of the lateral ventricle The inferior surface is continuous with the tegmentum of the midbrain medial surface of the thalamus forms the superior part of the lateral wall of the third ventricle and is usually connected to the opposite thalamus by a band of gray matter, the interthalamic connection lateral surface of the thalamus is separated from the lentiform nucleus by the very important band of white matter called the internal capsule

12. Function of thalamus 1- very important cell station that receives the main sensory tracts (except the olfactory pathway) 2- plays a key role in the integration of visceral and somatic functions Other functions will be discussed later

13. Subthalamus inferior to the thalamus between the thalamus and the tegmentum of the midbrain craniomedially, it is related to the hypothalamus Among the collections of nerve cells found in the subthalamus are - cranial ends of the red nuclei - substantia nigra - subthalamic nucleus involved in the control of muscle activity - The subthalamus also contains many important tracts that pass up from the tegmentum to the thalamic nuclei; the cranial ends of the medial, spinal, and trigeminal lemnisci are examples

14. Nuclei of the thalamus

15. Epithalamus - consists of the habenular nuclei and their connections and the pineal gland Habenular Nucleus small group of neurons situated just medial to the posterior surface of the thalamus

16. Sagittal section of the brain showing the medial surface of the diencephalon

17. - Pineal Gland (Body) a small, conical structure that is attached by the pineal stalk to the diencephalon Relations: - dorsally by splenium of corpus callosum - ventrally by midbrain - sup, post part of 3 rd ventricle - inf, cerebellar vermis - consist of pinealocytes and the glial cells - Calcifications may be found normally at age of 16 - cysts may be found (pineal cyst)

18. Photomicrograph of a section of the pineal gland stained with hematoxylin and eosin

19. Functions of the Pineal Gland - an important endocrine gland capable of influencing the activities of the pituitary gland. the islets of Langerhans of the pancreas, the parathyroids, the adrenal cortex and the adrenal medulla, and the gonads. - Melatonin and the enzymes needed for its production are present in high concentrations within the pineal gland - pineal gland plays an important role in the regulation of reproductive function

20. Hypothalamus is that part of the diencephalon that extends from the region of the optic chiasma to the caudal border of the mammillary bodies It lies below the hypothalamic sulcus on the lateral wall of the third ventricle Physiologically, there is hardly any activity in the body that is not influenced by the hypothalamus The hypothalamus controls and integrates the functions of the autonomic nervous system and the endocrine systems and plays a vital role in maintaining body homeostasis. It is involved in such activities as regulation of body temperature, body fluids, drives to eat and drink, sexual behavior, and emotion

21. Relations of the Hypothalamus Anterior to the hypothalamus: preoptic area Caudally, the hypothalamus merges into the tegmentum of the midbrain Superiorly is the thalamus Inferolaterally lies the subthalamic region When observed from below, the hypothalamus is seen to be related to the following structures, from anterior to posterior: (1) the optic chiasma, (2) the infundibulum and the tuber cinereum, and (3) the mammillary bodies

22. Optic Chiasma The optic chiasma is a flattened bundle of nerve fibers situated at the junction of the anterior wall and floor of the third ventricle

23. Tuber Cinereum a convex mass of gray matter, as seen from the inferior surface It is continuous inferiorly with the infundibulum Mammillary Bodies two small hemispherical bodies situated side by side posterior to the tuber cinereum

24. Ventricular cavities of the brain. A: Lateral view. B: Superior view

25. Superior view of the cerebral hemispheres.

26. Lateral view of the right cerebral hemisphere

28. Lateral view of the right cerebral hemisphere dissected to reveal the right insula

29. General Appearance of the Cerebral Hemispheres the largest part of the brain; they are separated by a deep midline sagittal fissure, the longitudinal cerebral fissure The fissure contains the sickle-shaped fold of dura mater, the falx cerebri, and the anterior cerebral arteries. great commissure, the corpus callosum, connects the hemispheres across the midline A second horizontal fold of dura mater separates the cerebral hemispheres from the cerebellum and is called the tentorium cerebelli

30. To increase the surface area of the cerebral cortex maximally, the surface of each cerebral hemisphere is thrown into folds or gyri, which are separated from each other by sulci or fissures each hemisphere are devided into lobes, which are named according to the cranial bones under which they lie. The central, parieto-occipital, lateral and calcarine sulci are boundaries used for the division of the cerebral hemisphere into frontal, parietal, temporal, and occipital lobes

31. Main Sulci The central sulcus (fissure of Rolanad) it begin aproximately midway between frontal and occopital pole and terminates just above the lateral sulcus, separate between frontal and parietal, motor (area 4) and sensory (area 1-3), precentral and postcentral gyrus Clinically it is related to anterior (frontal) branch of the middle meningeal artery which is important as a common site of injury during head trauma resulting in extradural hematoma. The lateral sulcus, a deep cleft found mainly on the inferior and lateral surfaces of the cerebral hemisphere, divides into the anterior horezontal ramus (anterior) and the anterior ascending ramus (ascending) and continues as the posterior ramus Anterir to the anterior horezontal ramus (anterior) is the pars orbitalis, between the anterior horezontal ramus (anterior) and the anterior ascending ramus (ascending) is the pars triangularis (motor speech area – brochas area), posterior to the anterior ascending ramus (ascending) is pars opercularis Clinically it is related to middle cerebral artery An area of cortex called the insula lies at the bottom of the deep lateral sulcus and cannot be seen from the surface unless the lips of the sulcus are separated

32. The parieto-occipital sulcus begins on the superior medial margin of the hemisphere about 2 inches (5 cm) anterior to the occipital pole, It passes downward and anteriorly on the medial surface to meet the calcarine sulcus forming a Y shaped appearance The calcarine sulcus is found on the medial surface of the hemisphere It commences under the posterior end of the corpus callosum and arches upward and backward to reach the occipital pole The calcarine sulcus is joined at an acute angle by the parieto- occipital sulcus

33. Superior view of the cerebral hemispheres

34. Lateral view of the right cerebral hemisphere

36. Lateral view of the right cerebral hemisphere showing the main sulci. B: Medial view of the right cerebral hemisphere showing the main sulci.

37. Lobes of the Cerebral Hemisphere The frontal lobe occupies the area anterior to the central sulcus and superior to the lateral sulcus (precentral gyrus, superior frontal gyrus, middle frontal gyrus and inferior frontal gyrus ) The parietal lobe occupies the area posterior to the central sulcus and superior to the lateral sulcus; it extends posteriorly as far as the parieto-occipital sulcus (postcentral gyrus, superior parietal lobule (gyrus), and the inferior parietal lobule (gyrus).) The superior and inferior parietal gyri are separated by the intra-parietal sulcus The temporal lobe occupies the area inferior to the lateral sulcus, superior and middle (inferior) temporal sulcus devide the lobe into superior, middle, and inferior temporal gyri The occipital lobe the occipitotemporal sulcus forms the medial and lateral occipitotemporal gyri (on the inferior surface of the cerebrum) The occipital lobe contain the lunate sulcus (behind which is the visual area –area 17) on superolateral sulcus

38. Medial and Inferior Surfaces of the Hemisphere many important areas that should be recognized The corpus callosum, which is the largest commissure of the brain, forms a striking feature on this surface cingulate gyrus begins beneath the anterior end of the corpus callosum and continues above the corpus callosum until it reaches its posterior end, The gyrus is separated from the corpus callosum by the callosal sulcus. The cingulate gyrus is separated from the superior frontal gyrus by the cingulate sulcus Inferior surface of the frontal lobe (orbital surface) devided by orbital sulci (H- shaped sulci) into anterior orbital, posterior orbital, lateral orbital and medial orbital gyei

39. Medial view of the cerebral hemisphere

40. The precuneus: is an area of cortex bounded anteriorly by the upturned posterior end of the cingulate sulcus and posteriorly by the parieto-occipital sulcus The cuneus: is a triangular area of cortex bounded above by the parieto-occipital sulcus, inferiorly by the calcarine sulcus, and posteriorly by the superior medial margin. The collateral sulcus is situated on the inferior surface of the hemisphere. It runs anteriorly below the calcarine sulcus. lingual gyrus Between the collateral sulcus and the calcarine sulcus. Anterior to the lingual gyrus is the parahippocampal gyrus; the latter terminates in front as the hooklike uncus