1. Anatomy and Physiology Anatomy (What) – Describes the structures of the body What they are made of Where they are located Associated structures Physiology (How) – Is the study of: Functions of anatomical structures Individual and cooperative functions

2. Relationships between Anatomy and Physiology Anatomy – Gross anatomy, or macroscopic anatomy, examines large, visible structures – Microscopic anatomy examines cells and molecules Cytology: study of cells and their structures – cyt- = cell Histology: study of tissues and their structures

3. Relationships between Anatomy and Physiology Physiology – Cell physiology: processes within and between cells – Organ physiology: functions of specific organs – Systemic physiology: functions of an organ system – Pathological physiology: effects of diseases

4. Levels of Organization The Chemical (or Molecular) Level – Atoms are the smallest chemical units – Molecules are a group of atoms working together The Cellular Level – Cells are a group of atoms, molecules, and organelles working together The Tissue Level – A tissue is a group of similar cells working together The Organ Level – An organ is a group of different tissues working together

5. Levels of Organization The Organ System Level – An organ system is a group of organs working together – Humans have 11 organ systems The Organism Level – A human is an organism

6. Figure 1-1 Levels of Organization Chemical and Molecular Levels Cellular Level Atoms in combination Complex protein molecule Protein filaments Heart muscle cell

7. Figure 1-1 Levels of Organization Tissue Level Organ Level Cardiac muscle tissue The heart The cardiovascular system Organ system level Organism level

8. Anatomical Terminology Superficial Anatomy – Locating structures on or near the body surface Anatomical Landmarks – Anatomical position: hands at sides, palms forward – Supine: lying down, face up – Prone: lying down, face down

9. Anatomical Terminology Superficial Anatomy – Anatomical Landmarks References to palpable structures – Anatomical Regions Body regions Abdominopelvic quadrants Abdominopelvic regions – Anatomical Directions Reference terms based on subject

10. Figure 1-5a Anatomical Landmarks Cephalic or head Frontal or forehead Cranial or skull Facial or face Oral or mouth Mental or chin Axillary or armpit Brachial or arm Antecubital or front of elbow Umbilical or navel Trunk Abdominal (abdomen) Mammary or breast Thoracic or thorax, chest Cervical or neck Buccal or cheek Otic or ear Nasal or nose Ocular, orbital or eye Anterior view

11. Figure 1-5a Anatomical Landmarks Antebrachial or forearm Carpal or wrist Palmar or palm Pollex or thumb Digits (phalanges) or fingers (digital or phalangeal) Patellar or kneecap Crural or leg Digits (phalanges) or toes (digital or phalangeal) Tarsal or ankle Anterior view Hallux or great toe Pedal or foot Femoral or thigh Pubic (pubis) Inguinal or groin Manual or hand Pelvic (pelvis) Trunk

12. Figure 1-5b Anatomical Landmarks Acromial or shoulder Olecranal or back of elbow Dorsal or back Upper limb Cervical or neck Cephalic or head Posterior view

13. Figure 1-5b Anatomical Landmarks Posterior view Lumbar or loin Gluteal or buttock Popliteal or back of knee Sural or calf Calcaneal or heel of foot Plantar or sole of foot Lower limb Upper limb

14. Figure 1-6a Abdominopelvic Quadrants and Regions Abdominopelvic quadrants. The four abdominopelvic quadrants are formed by two perpendicular lines that intersect at the navel. The terms for these quadrants, or their abbreviations, are most often used in clinical discussions. Right Upper Quadrant (RUQ) Right Lower Quadrant (RLQ) Left Upper Quadrant (LUQ) Left Lower Quadrant (LLQ)

15. Figure 1-6b Abdominopelvic Quadrants and Regions Right hypochondriac region Right lumbar region Right inguinal region Abdominopelvic regions. The nine abdominopelvic regions provide more precise regional descriptions. Left hypochondriac region Left lumbar region Left inguinal region Epigastric region Umbilical region Hypogastric (pubic) region

16. Figure 1-6c Abdominopelvic Quadrants and Regions Stomach Spleen Urinary bladder Liver Gallbladder Large intestine Small intestine Appendix Anatomical relationships. The relationship between the abdominopelvic quadrants and regions and the locations of the internal organs are shown here.

17. Figure 1-7 Directional References Cranial Posterior or dorsal Anterior or ventral Caudal A lateral view. Superior Right Left Lateral Proximal Medial Proximal Distal Inferior An anterior view. Arrows indicate important directional terms used in this text; definitions and descriptions are given in Table 1  2.

18. Table 1-2 Directional Terms

19. Anatomical Terminology Sectional Anatomy – Planes and sections Plane: a three-dimensional axis Section: a slice parallel to a plane Used to visualize internal organization and structure Important in radiological techniques (eg. MRI)

20. Figure 1-8 Sectional Planes Frontal plane Transverse plane Sagittal plane

21. Body Cavities Essential Functions of Body Cavities 1. Protect organs from accidental shocks 2. Permit changes in size and shape of internal organs Ventral body cavity – Divided by the diaphragm Thoracic cavity Abdominopelvic cavity

22. Body Cavities Serous Membranes – Line body cavities and cover organs – Consist of parietal layer and visceral layer Parietal layer — lines cavity Visceral layer — covers organ

23. Figure 1-10b The Ventral Body Cavity and Its Subdivisions Visceral pericardium Pericardial cavity Parietal pericardium Heart Air space Balloon

24. Figure 1-9 Relationships among the Subdivisions of the Ventral Body Cavity Provides protection Allows organ movement Linings prevent friction Ventral Body Cavity Thoracic Cavity Surrounded by chest wall and diaphragm Surrounds right lung Contains the trachea, esophagus, and major vessels Mediastinum Right Pleural Cavity Peritoneal Cavity Surrounds left lung Subdivides during development into Surrounds heart Pericardial Cavity Contains many digestive glands and organs Abdominal Cavity Abdominopelvic Cavity Extends throughout abdominal cavity and into superior portion of pelvic cavity Pelvic Cavity Contains urinary bladder, reproductive organs, last portion of digestive tract Left Pleural Cavity

25. Figure 1-10a The Ventral Body Cavity and Its Subdivisions POSTERIORANTERIOR Pleural cavity Pericardial cavity Thoracic cavity Peritoneal cavity Abdominal cavity Pelvic cavity Diaphragm Abdominopelvic cavity

26. Figure 1-10c The Ventral Body Cavity and Its Subdivisions Spinal cord Mediastinum Parietal pleura Pleural cavity Pericardial cavity Right lung POSTERIOR Left lung ANTERIOR

27. Body Cavities The Thoracic Cavity – Right and left pleural cavities Contain right and left lungs – Mediastinum Upper portion filled with blood vessels, trachea, esophagus, and thymus Lower portion contains pericardial cavity – The heart is located within the pericardial cavity

28. Figure 1-10c The Ventral Body Cavity and Its Subdivisions Spinal cord Mediastinum Parietal pleura Pleural cavity Pericardial cavity Right lung POSTERIOR Left lung ANTERIOR

29. Figure 1-10a The Ventral Body Cavity and Its Subdivisions POSTERIORANTERIOR Pleural cavity Pericardial cavity Thoracic cavity Peritoneal cavity Abdominal cavity Pelvic cavity Diaphragm Abdominopelvic cavity

30. Body Cavities The Abdominopelvic Cavity – Abdominal cavity — superior portion Diaphragm to top of pelvic bones Contains digestive organs Retroperitoneal space – Area posterior to peritoneum and anterior to muscular body wall – Contains pancreas, kidneys, ureters, and parts of the digestive tract

31. Body Cavities The Abdominopelvic Cavity – Pelvic cavity — inferior portion Within pelvic bones Contains reproductive organs, rectum, and bladder

32. Figure 1-10a The Ventral Body Cavity and Its Subdivisions POSTERIORANTERIOR Pleural cavity Pericardial cavity Thoracic cavity Peritoneal cavity Abdominal cavity Pelvic cavity Diaphragm Abdominopelvic cavity

33. Homeostasis – All body systems working together to maintain a stable internal environment Systems respond to external and internal changes to function within a normal range (body temperature, fluid balance)

34. Homeostasis Mechanisms of Regulation – Autoregulation (intrinsic) Automatic response in a cell, tissue, or organ to some environmental change – Extrinsic regulation Responses controlled by nervous and endocrine systems

35. Homeostasis Receptor – Receives the stimulus Control center – Processes the signal and sends instructions Effector – Carries out instructions

36. Figure 1-2 The Control of Room Temperature Normal condition disturbed Information affects RECEPTOR Thermometer HOMEOSTASIS STIMULUS: Room temperature rises Normal room temperature RESPONSE: Room temperature drops CONTROL CENTER (Thermostat) Normal condition restored EFFECTOR Air conditioner turns on Sends commands to 20°30°40° In response to input from a receptor (a thermometer), a thermostat (the control center) triggers an effector response (either an air condi- tioner or a heater) that restores normal temperature. In this case, when room temperature rises above the set point, the thermostat turns on the air conditioner, and the temperature returns to normal. With this regulatory system, room temperature fluctuates around the set point. Air conditioner turns on Air conditioner turns off Time Room temperature (°C) 22 Normal range

37. Negative and Positive Feedback The Role of Negative Feedback – The response of the effector negates the stimulus – Body is brought back into homeostasis Normal range is achieved

38. Figure 1-3 Negative Feedback in the Control of Body Temperature Normal temperature disturbed Information affects RECEPTORS Temperature sensors in skin and hypothalamus HOMEOSTASIS STIMULUS: Body temperature rises Normal body temperature RESPONSE: Increased heat loss, body temperature drops CONTROL CENTER Normal temperature restored EFFECTORS Sweat glands in skin increase secretion Blood vessels in skin dilate Sends commands to Events in the regulation of body temperature, which are comparable to those shown in Figure 1  2. A control center in the brain (the hypothalamus) functions as a thermostat with a set point of 37°C. If body temperature exceeds 37.2°C, heat loss is increased through enhanced blood flow to the skin and increased sweating. The thermoregulatory center keeps body temperature fluctuating within an acceptable range, usually between 36.7 and 37.2°C. Vessels dilate, sweating increases Vessels constrict, sweating decreases Time Body temperature (°C) 37.2 Normal range 37 36.7 Thermoregulatory center in brain

39. Negative and Positive Feedback The Role of Positive Feedback – The response of the effector increases change of the stimulus – Body is moved away from homeostasis Normal range is lost – Used to speed up processes

40. Figure 1-4 Positive Feedback: Blood Clotting Clotting accelerates Positive feedback loop Blood clot Chemicals This escalating process is a positive feedback loop that ends with the formation of a blood clot, which patches the vessel wall and stops the bleeding. As clotting continues, each step releases chemicals that further accelerate the process. The chemicals start chain reactions in which cells, cell fragments, and soluble proteins in the blood begin to form a clot. Damage to cells in the blood vessel wall releases chemicals that begin the process of blood clotting. Chemicals

42. Negative and Positive Feedback Systems Integration – Systems work together to maintain homeostasis Homeostasis is a state of equilibrium – Opposing forces are in balance – Dynamic equilibrium — continual adaptation Physiological systems work to restore balance – Failure results in disease or death

43. Table 1-1 The Roles of Organ Systems in Homeostatic Regulation

44. Come up with 5 multiple choice questions (a,b,c,d) that you think would be good for the quiz on Monday. Be sure to include the correct answer on the back of the sheet. Write them on a separate sheet of paper with your name on it. This will be a graded assignment.