1. Using SRDR™ For Systematic Reviews of Diagnostic Tests SRDR is being developed and maintained by the Brown EPC under contract with the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. HHSA 290-2012-00012-I). Quarterly Training # 3 November 7, 2013 2:00pm-3:00pm (ET)

2. Presentation outline Objectives Part 1 – SRDR overview Part 2 –Diagnostic Test SR project in SRDR Part 3 – Data exporting Summary 2 SRDR Quarterly training #3 November, 2013

3. Presentation outline Objectives Part 1 – SRDR overview Part 2 –Diagnostic Test SR project in SRDR Part 3 – Data exporting Summary 3 SRDR Quarterly training #3 November, 2013

4. Objectives Provide a brief overview of the SRDR structure and current features Discuss and demonstrate creation of Diagnostic Test systematic review project in SRDR Discuss and demonstrate simple and advance data exporting tool 4 SRDR Quarterly training #3 November, 2013

5. Presentation outline Objectives Part 1 – SRDR overview Part 2 –Diagnostic Test SR project in SRDR Part 3 – Data exporting Summary 5 SRDR Quarterly training #3 November, 2013

6. Data flow in systematic reviews Screening titles/abstracts Screening full-text articles Data abstraction from eligible trials/studies 6

7. System Status System has been in development for over 3 years Website launched in June 2012 Hosted on the AHRQ server Trademarked as Systematic Review Data Repository (SRDR™) SRDR is committed to a policy of open access. All completed systematic review projects deposited in the SRDR archive are publically available under the terms of a Creative Commons license Current data contributors are EPCs and other participating organizations (e.g., Cochrane, GIN, NICE) 7

8. System Status # of users/projects: Current data contributors are EPCs and other participating organizations (e.g., Cochrane, GIN, NICE) There are approximately 80-90 ongoing projects in the system and over 200 certified users. Features: Interfaces for creating abstraction forms and abstracting study data are in place, with improvements being continually implemented Tools for data retrieval/summarization and sharing have been developed, with new features in the pipeline Users support: Training materials including user manual, instructional videos, and an FAQ are available in the Help section linked to the SRDR homepage 8 8 SRDR Quarterly training #3 November, 2013

9. 9 System Structure Project: All data deposited within the SRDR are organized as individual projects. A project contains all information related to one systematic review (e.g., extraction forms, key questions, extracted studies, etc.) Key Question(s): The specific scientific queries an SRDR project is intended to address. All projects must include at least one key question Extraction Form: The user-defined dialogue by which collaborators extract data from relevant publications into an SRDR project Study: An individual publication extraction, consisting of one instance of a filled out extraction form 9

10. Presentation outline Objectives Part 1 – SRDR overview Part 2 –Diagnostic Test SR project in SRDR Part 3 – Data exporting Summary 10 SRDR Quarterly training #3 November, 2013

11. Diagnostic Test SR project example 11SRDR Quarterly training #3 November, 2013

12. Extraction Form 12SRDR Quarterly training #3 November, 2013

13. Results Screen 13SRDR Quarterly training #3 November, 2013

14. Presentation outline Objectives Part 1 – SRDR overview Part 2 –Diagnostic Test SR project in SRDR Part 3 – Data exporting Summary 14 SRDR Quarterly training #3 November, 2013

15. Data Export Tool 15SRDR Quarterly training #3 November, 2013

16. 2 export options 16SRDR Quarterly training #3 November, 2013

17. Simple data export tool Complete data set is exported to Microsoft Excel Worksheets divide the document into sections of the associated extraction form One file is exported per extraction form Each study data may be represented by one or more rows in the spreadsheet The Excel is storable and can be exported into Access A refreshed copy of each project is cached for download every 10 minutes Each download will have a timestamp indicating the time of last update 17 SRDR Quarterly training #3 November, 2013

18. Advanced data export tool Filter export table based on specific study attributes Choose desired data fields for inclusion Great for summary table creation Example: – Give me all RCTs – Containing Outcome A – Containing Arms A and B – Limit the output table to Mean and Standard Deviation Matrix Filtering expedites the process of finding interesting combinations of attributes – Study counts show prevalence of attributes in real-time 18 SRDR Quarterly training #3 November, 2013

19. Presentation outline Objectives Part 1 – SRDR overview Part 2 –Diagnostic Test SR project in SRDR Part 3 – Data exporting Summary 19 SRDR Quarterly training #3 November, 2013